ArticleFrontiers in neuroengineering2014
Deep brain stimulation macroelectrodes compared to multiple microelectrodes in rat hippocampus.
Article in Frontiers in neuroengineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Cerebellar deep brain stimulation rescues Purkinje cell mitochondrial density in a genetic mouse model of cerebellar ataxia.Brain research bulletin · 2026Article
- Magnetoelectric nanodiscs enable wireless transgene-free neuromodulation.Nature nanotechnology · 2025Article
- Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures.Heliyon · 2024Article
- Article
- Exploring CVD Method for Synthesizing Carbon-Carbon Composites as Materials to Contact with Nerve Tissue.Journal of functional biomaterials · 2023Article
- Modular pipeline for reconstruction and localization of implanted intracranial ECoG and sEEG electrodes.PloS one · 2023Article
- Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.Light, science & applications · 2022Article
- Cleanroom strategies for micro- and nano-fabricating flexible implantable neural electronics.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Microdialysis and microperfusion electrodes in neurologic disease monitoring.Fluids and barriers of the CNS · 2021Review
- 3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects.Science advances · 2021Article
- Imaging the Efficiency of Poly(3,4-ethylenedioxythiophene) Doped with Acid-Functionalized Carbon Nanotube and Iridium Oxide Electrode Coatings for Microstimulation.Advanced nanobiomed research · 2021Article
- Electrode Materials for Chronic Electrical Microstimulation.Advanced healthcare materials · 2021Review
- The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes.Frontiers in neuroscience · 2019Review
- Chronically Implanted Microelectrodes CauseFrontiers in neuroscience · 2019Article
- Machine Learning Based Classification of Deep Brain Stimulation Outcomes in a Rat Model of Binge Eating Using Ventral Striatal Oscillations.Frontiers in psychiatry · 2018Article
- Article
- A critical reflection on the technological development of deep brain stimulation (DBS).Frontiers in human neuroscience · 2014Article
- Asynchronous Distributed Multielectrode Microstimulation Reduces Seizures in the Dorsal Tetanus Toxin Model of Temporal Lobe Epilepsy.Brain stimulationArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microelectrode arrays (wire diameter <50 μm) were compared to traditional macroelectrodes for deep brain stimulation (DBS). Understanding the neuronal activation volume may help solve some of the mysteries associated with DBS, e.g., its mechanisms of action. We used c-fos immunohistochemistry to investigate neuronal activation in the rat hippocampus caused by multi-micro- and macroelectrode stimulation. At ± 1V stimulation at 25 Hz, microelectrodes (33 μm diameter) had a radius of activation of 100 μm, which is 50% of that seen with 150 μm diameter macroelectrode stimulation. Macroelectrodes activated about 5.8 times more neurons than a single microelectrode, but displaced ~20 times more neural tissue. The sphere of influence of stimulating electrodes can be significantly increased by reducing their impedance. By ultrasonic electroplating (sonicoplating) the microelectrodes with platinum to increase their surface area and reduce their impedance by an order of magnitude, the radius of activation increased by 50 μm and more than twice the number of neurons were activated within this increased radius compared to unplated microelectrodes. We suggest that a new approach to DBS, one that uses multiple high-surface area microelectrodes, may be more therapeutically effective due to increased neuronal activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.