ArticleBehavioural neurology2014
Heterogeneity of radiological spectrum in tacrolimus-associated encephalopathy after lung transplantation.
Article in Behavioural neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Late-onset tacrolimus-induced encephalopathy in lung transplant recipient: Case report.Heliyon · 2024Article
- Optimizing the initial tacrolimus dosage in Chinese children with lung transplantation within normal hematocrit levels.Frontiers in pediatrics · 2024Article
- Weight,Current pharmaceutical design · 2024Article
- Tacrolimus induced optic neuropathy in post-lung transplant patients: A series of 3 patients.American journal of ophthalmology case reports · 2021Article
- Pearls & Oy-sters: Tacrolimus neurotoxicity presenting as an isolated brainstem lesion.Neurology · 2016Article
- Posterior reversible encephalopathy syndrome during the peripartum period: report of four cases and review of the literature.International journal of clinical and experimental medicine · 2015Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
backgroundTacrolimus-associated encephalopathy (TAC-E) is usually described under the term of posterior reversible encephalopathy syndrome (PRES). However, a large amount of data has suggested that TAC-E is not a homogenous entity: indeed, TAC-E which is often presented with atypical and potentially misleading imaging characteristics does not always correspond to PRES.
objectiveWe aimed to identify the spectrum of brain MR imaging of TAC-E and discuss the underlying pathophysiological features.
methodsFrom September 2008 to October 2010, the neurological statuses of 45 patients, who underwent lung transplantation with TAC as posttransplantation immunosuppressive therapy, were regularly assessed in a prospective study. MRI was repeatedly performed, until recovery, in patients who developed central neurological symptoms.
resultsSymptoms suggestive of encephalopathy occurred in five out of 45 patients (11.1%). According to our MRI study, two patients presented with reversible bilateral and relatively symmetric subcortical white matter edema with proximal vasospasms on MRA; however, three other patients were characterized by coexistence of two different lesions including laminar cortical infarcts with hemorrhagic transformation not typically found in PRES and reversible deep white matter edema, associated with distal vasospasms on MRA.
conclusionsIt is considered that the mechanism of TAC-E would be more heterogenous than commonly perceived.
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