Evidence map›Paper›PMID 24970858›Full record

Trial reportJournal of dental research2014

Docosahexaenoic Acid and Periodontitis in Adults: A Randomized Controlled Trial.

A Z Naqvi, H Hasturk, L Mu, R S Phillips, R B Davis, S Halem, H Campos, J M Goodson, T E Van Dyke, K J Mukamal

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01976806 (The Effects of Docosahexaenoic Acid on Periodontitis in Adults), which is not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01976806 phase2completednot on this map

The Effects of Docosahexaenoic Acid on Periodontitis in Adults: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2009 to 2011Enrolled55ConditionsPeriodontitis, Gingivitis, InflammationArmsAspirin, Docosahexaenoic acid, Placebo (for Docosahexaenoic acid)
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  8. Safety of oil fromEFSA journal. European Food Safety Authority · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

A Z NaqviBeth Israel Deaconess Medical Center, Boston, MA, USA Harvard Medical School, Boston, MA, USA anaqvi@bidmc.harvard.edu.
H HasturkForsyth Institute, Cambridge, MA, USA.
L MuBeth Israel Deaconess Medical Center, Boston, MA, USA.
R S PhillipsBeth Israel Deaconess Medical Center, Boston, MA, USA Harvard Medical School, Boston, MA, USA.
R B DavisBeth Israel Deaconess Medical Center, Boston, MA, USA Harvard School of Public Health, Boston, MA, USA.
S HalemForsyth Institute, Cambridge, MA, USA Dentists Collaborative, North Andover, MA, USA.
H CamposHarvard School of Public Health, Boston, MA, USA.
J M GoodsonForsyth Institute, Cambridge, MA, USA.
T E Van DykeForsyth Institute, Cambridge, MA, USA.
K J MukamalBeth Israel Deaconess Medical Center, Boston, MA, USA Harvard School of Public Health, Boston, MA, USA.
Harvard University · USBeth Israel Deaconess Medical Center · US

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Research Training in Complementary and Integrative MedicineT32AT000051 · NCCIH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GLORIA Y YEH · 1999 to 2026
$10.2M
Neutrophils and Periodontitis in DiabetesR01DE015566 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI VAN DYKE, THOMAS ELLIOTT · 2005 to 2014
$4.2M
Novel Mechanisms in Resolution to Harness Inflammation for ReconstructionR01DE019938 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI IRIMIA, DANIEL, SERHAN, CHARLES NICHOLAS · 2009 to 2012
$2.7M
Research and Mentorship in Alternative MedicineK24AT000589 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PHILLIPS, RUSSELL SCOTT · 2001 to 2010
$1.5M
Treatment of Periodontitis and Inflammatory Changes in DiabetesK23DE018917 · NIDCR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HASTURK, HATICE · 2008 to 2012
$647k
NCATS NIH HHS 8UL1TR000170-05NCATS NIH HHS UL1 TR000170NCCIH NIH HHS K24 AT000589NCCIH NIH HHS K24AT000589NCCIH NIH HHS T32 AT000051NCCIH NIH HHS T32AT000051-10NIDCR NIH HHS DE15566NIDCR NIH HHS DE19938NIDCR NIH HHS K23 DE018917NIDCR NIH HHS K23DE18917NIDCR NIH HHS R01 DE015566NIDCR NIH HHS R01 DE019938
6 · The paper itself

Abstract

Periodontitis is a common chronic inflammatory disease initiated by bacteria, resulting in bone resorption, tooth loss, and systemic inflammation. Long-chain omega-3 fatty acids such as docosahexaenoic acid (DHA) reduce periodontitis in animals. We aimed to determine whether DHA supplementation with low-dose aspirin would reduce periodontitis in humans. We conducted a double-blind placebo-controlled parallel trial lasting 3 mo. Fifty-five adults with moderate periodontitis were randomized to 2,000 mg of DHA or identical soy/corn oil capsules. All participants received 81 mg of aspirin but received no other treatments. We analyzed the primary outcome of per-pocket change in pocket depth using mixed models among teeth with pocket depth ≥5 mm. Secondary outcomes assessed with generalized estimating equations included gingival index, plaque index, and bleeding on probing. Gingival crevicular fluid samples were analyzed for changes in high-sensitivity C-reactive protein (hsCRP) and interleukins 6 and 1β (IL-6 and IL-1β). Plasma was analyzed for changes in systemic inflammatory markers, including hsCRP. We confirmed adherence with erythrocyte fatty acid measurement. Forty-six participants completed the trial. While similar at baseline, the proportion of DHA in red blood cell plasma membranes increased from 3.6% ± 0.9% to 6.2% ± 1.6% in the intervention group but did not change among controls. DHA supplementation decreased mean pocket depth (-0.29 ± 0.13; p = .03) and gingival index (-0.26 ± 0.13; p = .04). Plaque index and bleeding on probing did not change. Significant adjusted differences were found between DHA and control for both gingival crevicular fluid hsCRP (-5.3 ng/mL, standard error [SE] = 2.4, p = .03) and IL-1β (-20.1 pg/mL, SE = 8.2, p = .02) but not IL-6 (0.02 pg/mL, SE = 0.71, p = .98) or systemic hsCRP (-1.19 mg/L, SE = 0.90, p = .20). In this randomized controlled trial, aspirin-triggered DHA supplementation significantly improved periodontal outcomes in people with periodontitis, indicating its potential therapeutic efficacy (clinicaltrials.gov NCT01976806).

Indexed as

AdultAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAspirinCell MembraneC-Reactive ProteinDental Plaque IndexDocosahexaenoic AcidsDouble-Blind MethodErythrocytesFemaleFollow-Up StudiesGingival Crevicular FluidHumansInflammation MediatorsInterleukin-1betaAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAspirinC-Reactive ProteinDocosahexaenoic AcidsIL6 protein, humanInflammation MediatorsInterleukin-1betaInterleukin-6Placebosclinical studyDHAfatty acidgingivitisinflammationomega-3

Identifiers

PMID24970858
PMCPMC4126225
OpenAlexW2098684195

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.