ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Surface tension in situ in flooded alveolus unaltered by albumin.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
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- High-fat diet obesity exacerbates acute lung injury-induced dysregulation of fatty acid oxidation in alveolar epithelial type 2 cells.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Alveolar distribution of nebulized solution in health and lung injury assessed by confocal microscopy.Physiological reports · 2024Article
- Comparative biophysical study of clinical surfactants using constrained drop surfactometry.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
- Implications of microscale lung damage for COVID-19 pulmonary ventilation dynamics: A narrative review.Life sciences · 2021Review
- Intravenous sulforhodamine B reduces alveolar surface tension, improves oxygenation, and reduces ventilation injury in a respiratory distress model.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Correlation of Serum Albumin Level to Lung Ultrasound Score and Its Role as Predictors of Outcome in Acute Respiratory Distress Syndrome Patients: A Prospective Observational Study.Critical care research and practice · 2021Article
- Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- The Contribution of Surface Tension-Dependent Alveolar Septal Stress Concentrations to Ventilation-Induced Lung Injury in the Acute Respiratory Distress Syndrome.Frontiers in physiology · 2020Article
- Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?American journal of respiratory and critical care medicine · 2019Review
- Tracheal acid or surfactant instillation raises alveolar surface tension.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Accelerated deflation promotes homogeneous airspace liquid distribution in the edematous lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Automated Droplet Manipulation Using Closed-Loop Axisymmetric Drop Shape Analysis.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Biophysical influence of airborne carbon nanomaterials on natural pulmonary surfactant.ACS nano · 2015Article
- Sulforhodamine B interacts with albumin to lower surface tension and protect against ventilation injury of flooded alveoli.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- On modeling edematous alveolar mechanics.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Lung ventilation injures areas with discrete alveolar flooding, in a surface tension-dependent fashion.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
In the acute respiratory distress syndrome, plasma proteins in alveolar edema liquid are thought to inactivate lung surfactant and raise surface tension, T. However, plasma protein-surfactant interaction has been assessed only in vitro, during unphysiologically large surface area compression (%ΔA). Here, we investigate whether plasma proteins raise T in situ in the isolated rat lung under physiologic conditions. We flood alveoli with liquid that omits/includes plasma proteins. We ventilate the lung between transpulmonary pressures of 5 and 15 cmH2O to apply a near-maximal physiologic %ΔA, comparable to that of severe mechanical ventilation, or between 1 and 30 cmH2O, to apply a supraphysiologic %ΔA. We pause ventilation for 20 min and determine T at the meniscus that is present at the flooded alveolar mouth. We determine alveolar air pressure at the trachea, alveolar liquid phase pressure by servo-nulling pressure measurement, and meniscus radius by confocal microscopy, and we calculate T according to the Laplace relation. Over 60 ventilation cycles, application of maximal physiologic %ΔA to alveoli flooded with 4.6% albumin solution does not alter T; supraphysiologic %ΔA raise T, transiently, by 51 ± 4%. In separate experiments, we find that addition of exogenous surfactant to the alveolar liquid can, with two cycles of maximal physiologic %ΔA, reduce T by 29 ± 11% despite the presence of albumin. We interpret that supraphysiologic %ΔA likely collapses the interfacial surfactant monolayer, allowing albumin to raise T. With maximal physiologic %ΔA, the monolayer likely remains intact such that albumin, blocked from the interface, cannot interfere with native or exogenous surfactant activity.
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