Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2014
Acute and long-term dysphagia in critically ill patients with severe sepsis: results of a prospective controlled observational study.
Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Persistent Features of Laryngeal Injury Following Endotracheal Intubation: A Systematic Review.Dysphagia · 2023Pooled it
- Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis.Intensive care medicine · 2020Pooled it
- The Prevalence of Infection and Sepsis Associated Dysphagia in Hospitalised Patients: A Retrospective Cross-sectional Study.Dysphagia · 2026Article
- Physiological barriers to oral intake in survivors of critical illness: A scoping review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Observational
- Impact of Single-Lumen Versus Double-Lumen Endotracheal Tube on Postoperative Swallowing Function in Lung Transplantation Patients: A Single-Center, Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Analysis of Patients' Dietary Status/Restrictions Following Instrumental Swallow Evaluations in Skilled Nursing Facilities.Dysphagia · 2025Article
- Be-SNAP: the Belgian Sepsis National Action Plan.Frontiers in public health · 2025Article
- Review
- Development and Effect Evaluation of an Action-Oriented Interdisciplinary Weaning Protocol for Cuffed Tracheostomy Tubes in Patients with Acquired Brain Injury.Healthcare (Basel, Switzerland) · 2024Article
- Evaluation and Treatment of Dysphagia in Public and Private Intensive Care Units (ICUs) in Greece.International archives of otorhinolaryngology · 2024Article
- Strategies of Screening and Treating Post-Extubation Dysphagia: An Overview of the Situation in Greek-Cypriot ICUs.Healthcare (Basel, Switzerland) · 2023Article
- [Slow demographic change and neurological rehabilitation-Part 1: state of affairs].Der Nervenarzt · 2023Review
- An International Commentary on Dysphagia and Dysphonia During the COVID-19 Pandemic.Dysphagia · 2022Review
- [Postextubation dysphagia in intensive care patients : Current findings and clinical recommendations].Die Anaesthesiologie · 2022Review
- Incidence, causes, and predictors of unsuccessful decannulation following prolonged weaning.Therapeutic advances in chronic disease · 2022Article
- Patients with dysphagia: How to supply nutrition through non-tube feeding.Frontiers in nutrition · 2022Review
- Laryngeal complications after tracheal intubation and tracheostomy.BJA education · 2021Review
- Translating Dysphagia Evidence into Practice While Avoiding Pitfalls: Assessing Bias Risk in Tracheostomy Literature.Dysphagia · 2021Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysphagia is a major risk factor for morbidity and mortality in critically ill patients treated in intensive care units (ICUs). Structured otorhinolaryngological data on dysphagia in ICU survivors with severe sepsis are missing. In a prospective study, 30 ICU patients with severe sepsis and thirty without sepsis as control group were examined using bedside fiberoptic endoscopic evaluation of swallowing after 14 days in the ICU (T1) and 4 months after onset of critical illness (T2). Swallowing dysfunction was assessed using the Penetration-Aspiration Scale (PAS). The Functional Oral Intake Scale was applied to evaluate the diet needed. Primary endpoint was the burden of dysphagia defined as PAS score >5. At T1, 19 of 30 severe sepsis patients showed aspiration with a PAS score >5, compared to 7 of 30 in critically ill patients without severe sepsis (p = 0.002). Severe sepsis and tracheostomy were independent risk factors for severe dysphagia with aspiration (PAS > 5) at T1 (p = 0.042 and 0.006, respectively). 4-month mortality (T2) was 57 % in severe sepsis patients compared to 20 % in patients without severe sepsis (p = 0.006). At T2, more severe sepsis survivors were tracheostomy-dependent and needed more often tube or parenteral feeding (p = 0.014 and p = 0.040, respectively). Multivariate analysis revealed tracheostomy at T1 as independent risk factor for severe dysphagia at T2 (p = 0.030). Severe sepsis appears to be a relevant risk factor for long-term dysphagia. An otorhinolaryngological evaluation of dysphagia at ICU discharge is mandatory for survivors of severe critical illness to plan specific swallowing rehabilitation programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.