ReviewBiomolecules2014
Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals.
Review in Biomolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 143 citations in OpenAlex.
- Metal-Driven Biochemical and Physiological Stress in Fish Inhabiting an Urban Coastal Lagoon: Evidence from an Integrated Multibiomarker Approach.Biological trace element research · 2026Article
- The evolutionary history of chelicerate metallothioneins reveals de novo emergence and metal-binding specialization across the subphylum.Scientific reports · 2026Article
- Metal-Coordination Specificity and Structural Dynamics of C. elegans Metallothionein I: Insights From 3D Modeling and MD Simulations.Proteins · 2026Article
- Structural analysis of bacterial metallothioneins involved in heavy metal detoxification.Bioinformation · 2026Article
- Advances in Mammalian Metallomics: New Insights into Metal Dynamics and Biological Significance.International journal of molecular sciences · 2025Review
- New insights into the role of metallothioneins in obesity and diabetes.International journal of obesity (2005) · 2025Review
- An Innovative Multi-Omics Approach Reveals the Interactions Between Honeybees and Their Environment.Animals : an open access journal from MDPI · 2025Article
- N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) as a novel chelator for Wilson's disease.Free radical biology & medicine · 2025Article
- A multi-domain snail metallothionein increases cadmium resistance and fitness in Caenorhabditis elegans.Scientific reports · 2024Article
- Multi-omic analysis of Huntington's disease reveals a compensatory astrocyte state.Nature communications · 2024Article
- Metals and metallothionein evolution in snails: a contribution to the concept of metal-specific functionality from an animal model group.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Role of zinc in health and disease.Clinical and experimental medicine · 2024Review
- Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state.bioRxiv : the preprint server for biology · 2023Article
- The Modular Architecture of Metallothioneins Facilitates Domain Rearrangements and Contributes to Their Evolvability in Metal-Accumulating Mollusks.International journal of molecular sciences · 2022Article
- Mechanism of Cadmium Exposure Induced Hepatotoxicity in the Mud Crab (Antioxidants (Basel, Switzerland) · 2022Article
- Effect of a Diet Supplemented with Nettle (Animals : an open access journal from MDPI · 2022Article
- ICP-MS Multi-Elemental Analysis of the Human Meninges Collected from Sudden Death Victims in South-Eastern Poland.Molecules (Basel, Switzerland) · 2022Article
- Tunicates Illuminate the Enigmatic Evolution of Chordate Metallothioneins by Gene Gains and Losses, Independent Modular Expansions, and Functional Convergences.Molecular biology and evolution · 2021Article
- Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions.Cancers · 2021Article
- The Enigmatic Metallothioneins: A Case of Upward-Looking Research.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallothioneins (MTs) are ubiquitous low molecular weight cysteine-rich proteins characterized by high affinity for d10 electron configuration metals, including essential (Zn and Cu) and non-essential (Cd and Hg) trace elements. The biological role of these ancient and well-conserved multifunctional proteins has been debated since MTs were first discovered in 1957. Their main hypothesized functions are: (1) homeostasis of Zn and Cu; (2) detoxification of Cd, and Hg; and (3) free radical scavenging. This review will focus on MTs in unconventional animals, those not traditionally studied in veterinary medicine but of increasing interest in this field of research. Living in different environments, these animals represent an incredible source of physiological and biochemical adaptations still partly unexplored. The study of metal-MT interactions is of great interest for clinicians and researchers working in veterinary medicine, food quality and endangered species conservation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.