Evidence map›Paper›PMID 24970206›Full record

ReviewBiomolecules2014

Long noncoding RNAs in imprinting and X chromosome inactivation.

Joseph M Autuoro, Stephan P Pirnie, Gordon G Carmichael

Abstract readReview
In one paragraph

Review in Biomolecules, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
  2. lncRNA HOTAIR and Cardiovascular diseases.Functional & integrative genomics · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Significance of lncRNA abundance to function.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph M AutuoroDepartment of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA. jautuoro@gmail.com.
Stephan P PirnieDepartment of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA. spirnie@student.uchc.edu.
Gordon G CarmichaelDepartment of Genetics and Developmental Biology, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA. carmichael@nso2.uchc.edu.

Funding

Nuclear-retained long noncoding RNAsR01HD072418 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CARMICHAEL, GORDON G · 2013 to 2017
$1.6M
NICHD NIH HHS HD072418NICHD NIH HHS R01 HD072418
6 · The paper itself

Abstract

The field of long noncoding RNA (lncRNA) research has been rapidly advancing in recent years. Technological advancements and deep-sequencing of the transcriptome have facilitated the identification of numerous new lncRNAs, many with unusual properties, however, the function of most of these molecules is still largely unknown. Some evidence suggests that several of these lncRNAs may regulate their own transcription in cis, and that of nearby genes, by recruiting remodeling factors to local chromatin. Notably, lncRNAs are known to exist at many imprinted gene clusters. Genomic imprinting is a complex and highly regulated process resulting in the monoallelic silencing of certain genes, based on the parent-of-origin of the allele. It is thought that lncRNAs may regulate many imprinted loci, however, the mechanism by which they exert such influence is poorly understood. This review will discuss what is known about the lncRNAs of major imprinted loci, and the roles they play in the regulation of imprinting.

Indexed as

Genomic ImprintingX Chromosome InactivationAnimalsGene SilencingHumansRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID24970206
PMCPMC4030979

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.