ArticleBiomolecules2013
Biocatalytic synthesis of chiral alcohols and amino acids for development of pharmaceuticals.
Article in Biomolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Chemo-, Diastereo-, and Enantioselective Radical Cyclization of Enals to Access Cyclopentanols Bearing an α-Quaternary Center.Angewandte Chemie (International ed. in English) · 2026Article
- Enzymatic synthesis of four stereoisomers of 3-substituted-4-hydroxypiperidines by carbonyl reductase-catalyzed reduction.RSC advances · 2025Article
- Highly efficient synthesis of the chiral ACE inhibitor intermediate (R)-2-hydroxy-4-phenylbutyrate ethyl ester via engineered bi-enzyme coupled systems.Bioresources and bioprocessing · 2024Article
- Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor.Communications chemistry · 2024Article
- A short-chain carbonyl reductase mutant is an efficient catalyst in the production of (R)-1,3-butanediol.Microbial biotechnology · 2023Article
- Enantioseparation in Hierarchically Porous Assemblies of Homochiral Cages.ACS central science · 2022Article
- Deracemization of 1-phenylethanols in a one-pot process combining Mn-driven oxidation with enzymatic reduction utilizing a compartmentalization technique.RSC advances · 2022Article
- Versatile selective evolutionary pressure using synthetic defect in universal metabolism.Nature communications · 2021Article
- Self-sufficient asymmetric reduction of β-ketoesters catalysed by a novel and robust thermophilic alcohol dehydrogenase co-immobilised with NADH.Catalysis science & technology · 2021Article
- Highly enantioselective synthesis of (R)-1,3-butanediol via deracemization of the corresponding racemate by a whole-cell stereoinverting cascade system.Microbial cell factories · 2020Article
- Overview on Multienzymatic Cascades for the Production of Non-canonical α-Amino Acids.Frontiers in bioengineering and biotechnology · 2020Review
- Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies.Biochemistry · 2018Article
- Cobalt-Catalyzed Carbonylative Cross-Coupling of Alkyl Tosylates and Dienes: Stereospecific Synthesis of Dienones at Low Pressure.Journal of the American Chemical Society · 2017Article
- DFT-based prediction of reactivity of short-chain alcohol dehydrogenase.Journal of computer-aided molecular design · 2017Article
- Integrated (Meta) Genomic and Synthetic Biology Approaches to Develop New Biocatalysts.Marine drugs · 2016Review
- Increased availability of NADH in metabolically engineered baker's yeast improves transaminase-oxidoreductase coupled asymmetric whole-cell bioconversion.Microbial cell factories · 2016Article
- Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent.Applied and environmental microbiology · 2015Article
- Asymmetric reduction of ketones and β-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum.Applied microbiology and biotechnology · 2015Article
- Engineered baker's yeast as whole-cell biocatalyst for one-pot stereo-selective conversion of amines to alcohols.Microbial cell factories · 2014Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates and drugs has become increasingly important in the pharmaceutical industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes derived there from for the transformation of synthetic chemicals with high chemo-, regio- and enatioselectivities. In this article, biocatalytic processes are described for the synthesis of chiral alcohols and unntural aminoacids for pharmaceuticals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.