Evidence map›Paper›PMID 24970180›Full record

ArticleBiomolecules2013

Carbonic anhydrases and their biotechnological applications.

Christopher D Boone, Andrew Habibzadegan, Sonika Gill, Robert McKenna

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Introduction to Carbonic Anhydrase.Sub-cellular biochemistry · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Multichannel dual protein sensing using amphiphilic supramolecular assemblies.Chemical communications (Cambridge, England) · 2021
    Article
  9. Review
  10. Article
  11. Biocatalytic COInternational journal of molecular sciences · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Non-Viral Delivery System and Targeted Bone Disease Therapy.International journal of molecular sciences · 2019
    Review
  16. Structural insights into a thermostable variant of human carbonic anhydrase II.Protein science : a publication of the Protein Society · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher D BooneBiochemistry & Molecular Biology, University of Florida, P.O. Box 100245, Gainesville, FL 32610, USA. cdboone@ufl.edu.
Andrew HabibzadeganBiochemistry & Molecular Biology, University of Florida, P.O. Box 100245, Gainesville, FL 32610, USA. ahabibzadegan@ufl.edu.
Sonika GillBiochemistry & Molecular Biology, University of Florida, P.O. Box 100245, Gainesville, FL 32610, USA. sonika22@ufl.edu.
Robert McKennaBiochemistry & Molecular Biology, University of Florida, P.O. Box 100245, Gainesville, FL 32610, USA. rmckenna@ufl.edu.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The carbonic anhydrases (CAs) are mostly zinc-containing metalloenzymes which catalyze the reversible hydration/dehydration of carbon dioxide/bicarbonate. The CAs have been extensively studied because of their broad physiological importance in all kingdoms of life and clinical relevance as drug targets. In particular, human CA isoform II (HCA II) has a catalytic efficiency of 108 M-1 s-1, approaching the diffusion limit. The high catalytic rate, relatively simple procedure of expression and purification, relative stability and extensive biophysical studies of HCA II has made it an exciting candidate to be incorporated into various biomedical applications such as artificial lungs, biosensors and CO2 sequestration systems, among others. This review highlights the current state of these applications, lists their advantages and limitations, and discusses their future development.

Identifiers

PMID24970180
PMCPMC4030944
OpenAlexW2052140340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.