ArticleBiomolecules2012
Molecular Insights into Poly(ADP-ribose) Recognition and Processing.
Article in Biomolecules, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Prospects for PARG inhibitors in cancer therapy.Journal of molecular cell biology · 2025Review
- Article
- Pathological and physiological roles of ADP-ribosylation: established functions and new insights.Biological chemistry · 2024Review
- Review
- Rapid Detection and Signaling of DNA Damage by PARP-1.Trends in biochemical sciences · 2021Review
- Phosphorylation of PUF-A/PUM3 on Y259 modulates PUF-A stability and cell proliferation.PloS one · 2021Article
- Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.Nature communications · 2019Article
- PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.Nature communications · 2018Article
- The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells.Leukemia & lymphoma · 2017Article
- What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.Methods in enzymology · 2017Review
- Functions of PARylation in DNA Damage Repair Pathways.Genomics, proteomics & bioinformatics · 2016Review
- PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.Nucleic acids research · 2016Article
- Article
- The rise and fall of poly(ADP-ribose): An enzymatic perspective.DNA repair · 2015Review
- A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.The Journal of biological chemistry · 2015Article
- The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites.Cell cycle (Georgetown, Tex.) · 2015Article
- Article
- Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response.Chromosoma · 2014Review
- Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation.Nature reviews. Molecular cell biology · 2013Review
- Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.The EMBO journal · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis. The amount of poly(ADP-ribosyl)ation (PAR) in cells reflects the balance of synthesis, mediated by the PARP protein family, and degradation, which is catalyzed by a glycohydrolase, PARG. Many of the proteins mediating PAR metabolism possess specialised high affinity PAR-binding modules that allow the efficient sensing or processing of the PAR signal. The identification of four such PAR-binding modules and the characterization of a number of proteins utilising these elements during the last decade has provided important insights into how PAR regulates different cellular activities. The macrodomain represents a unique PAR-binding module which is, in some instances, known to possess enzymatic activity on ADP-ribose derivatives (in addition to PAR-binding). The most recently discovered example for this is the PARG protein, and several available PARG structures have provided an understanding into how the PARG macrodomain evolved into a major enzyme that maintains PAR homeostasis in living cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.