ArticleScientific reports2014
Real-time measurement of membrane conformational states induced by antimicrobial peptides: balance between recovery and lysis.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Designing AI-generated antimicrobials for targeting bacterial microdomains.Scientific reports · 2025Article
- Lacritin cleavage-potentiated targeting of iron - respiratory reciprocity promotes bacterial death.The Journal of biological chemistry · 2025Article
- Gladiolin produced by pathogenicmBio · 2024Article
- The intricate link between membrane lipid structure and composition and membrane structural properties in bacterial membranes.Chemical science · 2024Review
- Article
- Investigating Membrane-Mediated Antimicrobial Peptide Interactions with Synchrotron Radiation Far-Infrared Spectroscopy.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Conformation and membrane interaction studies of the potent antimicrobial and anticancer peptide palustrin-Ca.Scientific reports · 2021Article
- Latest developments on the mechanism of action of membrane disrupting peptides.Biophysics reports · 2021Article
- Enhanced avidin binding to lipid bilayers using PDP-PE lipids with PEG-biotin linkers.Nanoscale advances · 2020Article
- Qualitative and Quantitative Changes toLangmuir : the ACS journal of surfaces and colloids · 2020Article
- Interaction of Silver-Lignin Nanoparticles With Mammalian Mimetic Membranes.Frontiers in bioengineering and biotechnology · 2020Article
- Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides.Frontiers in medical technology · 2020Review
- A comment by Prof. Mibel Aguilar-2018 recipient of the Australian Society for Biophysics' McAulay-Hope Prize for Original Biophysics.Biophysical reviews · 2019Article
- The cyclic peptide labaditin does not alter the outer membrane integrity of Salmonella enterica serovar Typhimurium.Scientific reports · 2019Article
- Biophysical Investigations Elucidating the Mechanisms of Action of Antimicrobial Peptides and Their Synergism.Biomolecules · 2018Review
- Antimicrobial peptides: biochemical determinants of activity and biophysical techniques of elucidating their functionality.World journal of microbiology & biotechnology · 2018Review
- Enhanced transdermal delivery with less irritation by magainin pore-forming peptide with a N-lauroylsarcosine and sorbitan monolaurate mixture.Drug delivery and translational research · 2018Article
- Antibacterial isoamphipathic oligomers highlight the importance of multimeric lipid aggregation for antibacterial potency.Communications biology · 2018Article
- One pathogen two stones: are Australian tree frog antimicrobial peptides synergistic against human pathogens?European biophysics journal : EBJ · 2017Article
- Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The disruption of membranes by antimicrobial peptides is a multi-state process involving significant structural changes in the phospholipid bilayer. However, direct measurement of these membrane structural changes is lacking. We used a combination of dual polarisation interferometry (DPI), surface plasmon resonance spectroscopy (SPR) and atomic force microscopy (AFM) to measure the real-time changes in membrane structure through the measurement of birefringence during the binding of magainin 2 (Mag2) and a highly potent analogue in which Ser(8), Gly(13) and Gly(18) has been replaced with alanine (Mag-A). We show that the membrane bilayer undergoes a series of structural changes upon peptide binding before a critical threshold concentration is reached which triggers a significant membrane disturbance. We also propose a detailed model for antimicrobial peptide action as a function of the degree of bilayer disruption to provide an unprecedented in-depth understanding of the membrane lysis in terms of the interconversion of different membrane conformational states in which there is a balance between recovery and lysis.
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