ArticleCerebral cortex (New York, N.Y. : 1991)2015
Supraspinal Control of Urine Storage and Micturition in Men--An fMRI Study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03855930 (Phantom Limb Pain Triggered by Micturition, An Functional Magnetic Resonance Imaging), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phantom Limb Pain Triggered by Micturition, An Functional Magnetic Resonance Imaging (FMRI) Study in Lower Limb Amputees
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- Brain activation during the voiding phase of micturition in healthy adults: A meta-analysis of neuroimaging studies.Clinical anatomy (New York, N.Y.) · 2019Pooled it
- A novel behavioral paradigm for odor-induced voluntary urination in mice.Scientific reports · 2026Article
- Identifying Abnormalities in Regional Brain Activity and Functional Connectivity in Patients With Detrusor Overactivity After Spinal Cord Injury.International neurourology journal · 2026Article
- The cerebro-pelvic axis: a unified framework linking higher brain function, pelvic floor control, and lower urinary tract dysfunction.Frontiers in neuroscience · 2026Article
- The mechanism of action of neuromodulation in the treatment of overactive bladder.Nature reviews. Urology · 2025Review
- A deeper exploration of functional connectivity of brain regions regulating bladder function in healthy adults.Continence (Amsterdam, Netherlands) · 2025Article
- A 7-tesla study of cerebellar alterations relating to bladder control in women with multiple sclerosis voiding dysfunction using functional connectivity.Clinical neuroimaging (Hoboken, N.J.) · 2025Article
- Cerebellar functional connectivity relates to lower urinary tract function: A 7 Tesla study.Neurourology and urodynamics · 2024Article
- A Pilot Study of Functional Brain Magnetic Resonance Imaging in BPS/IC Patients: Evidence of Central Sensitization.Urology research & practice · 2024Article
- Is the Brainstem Activation Different Between Healthy Young Male and Female Volunteers at Initiation of Voiding? A High Definition 7-Tesla Magnetic Resonance Imaging Study.International neurourology journal · 2023Article
- Abnormal Resting-State Network Presence in Females with Overactive Bladder.Biomedicines · 2023Article
- How brain diseases affect the lower urinary tract function?Bladder (San Francisco, Calif.) · 2023Review
- Androgen receptors in areas of the spinal cord and brainstem: A study in adult male cats.Journal of anatomy · 2021Article
- Parcellation of human periaqueductal gray at 7-T fMRI in full and empty bladder state: The foundation to study dynamic connectivity changes related to lower urinary tract functioning.Neurourology and urodynamics · 2021Article
- Regional brain atrophy in overactive bladder syndrome: a voxel based morphometry study.International urology and nephrology · 2021Article
- Are White Matter Tract Integrities Different in Multiple Sclerosis Women With Voiding Dysfunction?Female pelvic medicine & reconstructive surgery · 2021Observational
- Neurogenic Bladder: Epidemiology, Diagnosis, and Management.Seminars in neurology · 2020Review
- The Dual Nature of Onuf's Nucleus: Neuroanatomical Features and Peculiarities, in Health and Disease.Frontiers in neuroanatomy · 2020Review
- Functional brain imaging in voiding dysfunction.Current bladder dysfunction reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the crucial role of the brain in the control of the human lower urinary tract, little is known about the supraspinal mechanisms regulating micturition. To investigate the central regulatory mechanisms activated during micturition initiation and actual micturition, we used an alternating sequence of micturition imitation/imagination, micturition initiation, and actual micturition in 22 healthy males undergoing functional magnetic resonance imaging. Subjects able to micturate (voiders) showed the most prominent supraspinal activity during the final phase of micturition initiation whereas actual micturition was associated with significantly less such activity. Initiation of micturition in voiders induced significant activity in the brainstem (periaqueductal gray, pons), insula, thalamus, prefrontal cortex, parietal operculum and cingulate cortex with significant functional connectivity between the forebrain and parietal operculum. Subjects unable to micturate (nonvoiders) showed less robust activation during initiation of micturition, with activity in the forebrain and brainstem particularly lacking. Our findings suggest that micturition is controlled by a specific supraspinal network which is essential for the voluntary initiation of micturition. Once this network triggers the bulbospinal micturition reflex via brainstem centers, micturition continues automatically without further supraspinal input. Unsuccessful micturition is characterized by a failure to activate the periaqueductal gray and pons during initiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.