ArticleProceedings of the National Academy of Sciences of the United States of America2014
Major mouse placental compartments revealed by diffusion-weighted MRI, contrast-enhanced MRI, and fluorescence imaging.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Contrast-agent-free visualization of murine embryo-placental vasculature with ultrafast plane-wave ultrasound.Placenta · 2026Article
- The MRI two-perfusion IVIM model improves understanding of SARS-CoV-2 virus impact on placental tissue.Magma (New York, N.Y.) · 2026Article
- Diffusion-T2 correlated spectroscopy imaging to explore possible placental composition changes over gestation.BMC medical imaging · 2025Article
- Developments in functional imaging of the placenta.The British journal of radiology · 2023Review
- Deuterium Magnetic Resonance Imaging and the Discrimination of Fetoplacental Metabolism in Normal and L-NAME-Induced Preeclamptic Mice.Metabolites · 2021Article
- Phenotyping placental oxygenation in Lgals1 deficient mice usingScientific reports · 2021Article
- Multidimensional correlation MRI.NMR in biomedicine · 2020Article
- Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta.Scientific reports · 2020Article
- Molecular pathways of senescence regulate placental structure and function.The EMBO journal · 2019Article
- Combined diffusion-relaxometry MRI to identify dysfunction in the human placenta.Magnetic resonance in medicine · 2019Article
- Dynamic glucose enhanced MRI of the placenta in a mouse model of intrauterine inflammation.Placenta · 2018Article
- Placenta microstructure and microcirculation imaging with diffusion MRI.Magnetic resonance in medicine · 2018Article
- In vivo assessment of the placental anatomy and perfusion in a mouse model of intrauterine inflammation.Journal of magnetic resonance imaging : JMRI · 2018Article
- Placental physiology monitored by hyperpolarized dynamicProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diffusion MRI measurements in challenging head and brain regions via cross-term spatiotemporally encoding.Scientific reports · 2017Article
- Reducing SAR requirements in multislice volumetric single-shot spatiotemporal MRI by two-dimensional RF pulses.Magnetic resonance in medicine · 2017Article
- Robust diffusion tensor imaging by spatiotemporal encoding: Principles and in vivo demonstrations.Magnetic resonance in medicine · 2017Article
- Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging.PloS one · 2017Article
- A longitudinal study of placental perfusion using dynamic contrast enhanced magnetic resonance imaging in murine pregnancy.Placenta · 2016Article
- Longitudinal Changes in Placental Magnetic Resonance Imaging Relaxation Parameter in Murine Pregnancy: Compartmental Analysis.Gynecologic and obstetric investigation · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Mammalian models, and mouse studies in particular, play a central role in our understanding of placental development. Magnetic resonance imaging (MRI) could be a valuable tool to further these studies, providing both structural and functional information. As fluid dynamics throughout the placenta are driven by a variety of flow and diffusion processes, diffusion-weighted MRI could enhance our understanding of the exchange properties of maternal and fetal blood pools--and thereby of placental function. These studies, however, have so far been hindered by the small sizes, the unavoidable motions, and the challenging air/water/fat heterogeneities, associated with mouse placental environments. The present study demonstrates that emerging methods based on the spatiotemporal encoding (SPEN) of the MRI information can robustly overcome these obstacles. Using SPEN MRI in combination with albumin-based contrast agents, we analyzed the diffusion behavior of developing placentas in a cohort of mice. These studies successfully discriminated the maternal from the fetal blood flows; the two orders of magnitude differences measured in these fluids' apparent diffusion coefficients suggest a nearly free diffusion behavior for the former and a strong flow-based component for the latter. An intermediate behavior was observed by these methods for a third compartment that, based on maternal albumin endocytosis, was associated with trophoblastic cells in the interphase labyrinth. Structural features associated with these dynamic measurements were consistent with independent intravital and ex vivo fluorescence microscopy studies and are discussed within the context of the anatomy of developing mouse placentas.
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