ArticleAmerican journal of nephrology2014
Significant racial differences in the key factors associated with early graft loss in kidney transplant recipients.
Article in American journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Characteristics of mismatched eplets affecting de novo donor-specific antibody production and antibody-mediated rejection after kidney transplantation.BMC nephrology · 2025Article
- Advancing kidney transplantation in black patients: a genetics-based and personalized approach under NICE, KDIGO, and ERBP guidelines.Renal failure · 2024Review
- Glycemic management and clinical outcomes in underserved minority kidney transplant recipients with type 2 and posttransplantation diabetes: A single-center retrospective study.Diabetes research and clinical practice · 2020Article
- Predicting ideal outcome after pediatric liver transplantation: An exploratory study using machine learning analyses to leverage Studies of Pediatric Liver Transplantation Data.Pediatric transplantation · 2019Article
- The impact of time-varying clinical surrogates on disparities in African-American kidney transplant recipients - a retrospective longitudinal cohort study.Transplant international : official journal of the European Society for Organ Transplantation · 2019Article
- A qualitative examination of barriers and solutions to renal transplantation in Malaysia: Key-informants' perspective.PloS one · 2019Article
- Pharmacist-Led, Technology-Assisted Study to Improve Medication Safety, Cardiovascular Risk Factor Control, and Racial Disparities in Kidney Transplant Recipients.Journal of the American College of Clinical Pharmacy : JACCP · 2018Article
- Transplant Center Variability in Disparities for African-American Kidney Transplant Recipients.Annals of transplantation · 2018Article
- Xenotransplantation.Organogenesis · 2018Article
- Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation.Transplantation · 2017Article
- Cytolytic Induction Therapy Improves Clinical Outcomes in African-American Kidney Transplant Recipients.Annals of surgery · 2017Article
- Outcome disparities between African Americans and Caucasians in contemporary kidney transplant recipients.American journal of surgery · 2017Article
- Overall Graft Loss Versus Death-Censored Graft Loss: Unmasking the Magnitude of Racial Disparities in Outcomes Among US Kidney Transplant Recipients.Transplantation · 2017Article
- Impact of Cardiovascular Risk Factors on Graft Outcome Disparities in Black Kidney Transplant Recipients.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Quantifying the Race Stratified Impact of Socioeconomics on Graft Outcomes in Kidney Transplant Recipients.Transplantation · 2016Article
- Genomics in CKD: Is This the Path Forward?Advances in chronic kidney disease · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThere is continued and significant debate regarding the salient etiologies associated with graft loss and racial disparities in kidney transplant recipients.
methodsThis was a longitudinal cohort study of all adult kidney transplant recipients, comparing patients with early graft loss (<5 years) to those with graft longevity (surviving graft with at least 5 years of follow-up) across racial cohorts [African-American (AA) and non-AA] to discern risk factors.
results524 patients were included, 55% AA, 151 with early graft loss (29%) and 373 with graft longevity (71%). Consistent within both races, early graft loss was significantly associated with disability income [adjusted odds ratio (AOR) 2.2, 95% CI 1.1-4.5], Kidney Donor Risk Index (AOR 3.2, 1.4-7.5), rehospitalization (AOR 2.1, 1.0-4.4) and acute rejection (AOR 4.4, 1.7-11.6). Unique risk factors in AAs included Medicare-only insurance (AOR 8.0, 2.3-28) and BK infection (AOR 5.6, 1.3-25). Unique protective factors in AAs included cardiovascular risk factor control: AAs with a mean systolic blood pressure <150 mm Hg had 80% lower risk of early graft loss (AOR 0.2, 0.1-0.7), while low-density lipoprotein <100 mg/dl (AOR 0.4, 0.2-0.8), triglycerides <150 mg/dl (AOR 0.4, 0.2-1.0) and hemoglobin A1C <7% (AOR 0.2, 0.1-0.6) were also protective against early graft loss in AA, but not in non-AA recipients.
conclusionsAA recipients have a number of unique risk factors for early graft loss, suggesting that controlling cardiovascular comorbidities may be an important mechanism to reduce racial disparities in kidney transplantation.
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