Observational studyEuropean journal of pediatrics2015
Metabolic acidosis in the first 14 days of life in infants of gestation less than 26 weeks.
Observational study in European journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Quality of life of individuals born preterm: a systematic review of assessment approaches.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Pooled it
- Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea.Clinical and experimental pediatrics · 2026Article
- Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies.Pediatric research · 2026Review
- Sweet or Salty: Comparing Dextrose and Sodium Acetate Umbilical Arterial Catheter Fluids.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Metabolic acidosis as a risk factor for bronchopulmonary dysplasia in preterm infants born between 23 + 0 and 31 + 6 weeks of gestation: a retrospective case-control study.Frontiers in pediatrics · 2025Article
- Association between early metabolic acidosis and bronchopulmonary dysplasia/death in preterm infants born at less than 28 weeks' gestation: an observational cohort study.BMC pediatrics · 2024Observational
- An Extremely Preterm Infant Born at 23 Weeks' Gestation With an Interrupted Aortic Arch Complex: A Case Report.Cureus · 2023Article
- Risk factors and machine learning prediction models for bronchopulmonary dysplasia severity in the Chinese population.World journal of pediatrics : WJP · 2023Article
- Metabolic acidosis during continuous glucagon therapy for neonatal hypoglycemia.Paediatrics & child health · 2023Article
- The effects of sodium bicarbonate infusion on cerebrovascular function in newborn pigs.Pediatric research · 2022Article
- Use of intravenous sodium bicarbonate in neonatal intensive care units in Italy: a nationwide survey.Italian journal of pediatrics · 2021Article
- Renal aspects of metabolic acid-base disorders in neonates.Pediatric nephrology (Berlin, Germany) · 2020Review
- Article
- Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus.Clinical and translational science · 2019Article
- Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Acid-base equilibrium in premature infants: don't forget feeding type.European journal of pediatrics · 2015Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledExtremely immature newborns develop a self-limiting normal anion gap metabolic acidosis in early life. This study examined the natural history of this acidosis in a population of infants of gestation less than 26 weeks in the first 14 days of life. The acidosis was maximal on day 4 with a mean base deficit of 10.6 mmol/l and had resolved in 90 % of infants by day 11. Dopamine usage was the only independent predictor of the acidosis. Its use was associated with a greater degree of acidosis.
conclusionExtremely preterm infants experience a self-limiting normal anion gap metabolic acidosis in the first 2 weeks of life which is consistent with renal tubular immaturity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.