ArticleOncology nursing forum2014
The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.
Article in Oncology nursing forum, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prevalence of symptoms in children with acute lymphoblastic leukaemia: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- Multi-omics analysis of the gut microbiome and metabolites associated with the psychoneurological symptom cluster in children with cancer receiving chemotherapy.Journal of translational medicine · 2024Article
- Exploring core symptoms and interrelationships among symptoms in children with acute leukemia during chemotherapy: A network analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Article
- Inflammatory, Oxidative Stress, and Cardiac Damage Biomarkers and Radiation-Induced Fatigue in Breast Cancer Survivors.Biological research for nursing · 2022Article
- Targeting Redox Regulation as a Therapeutic Opportunity against Acute Leukemia: Pro-Oxidant Strategy or Antioxidant Approach?Antioxidants (Basel, Switzerland) · 2022Review
- Metabolic Pathways Associated With Psychoneurological Symptoms in Children With Cancer Receiving Chemotherapy.Biological research for nursing · 2022Article
- The Symptom Experience in Pediatric Cancer: Current Conceptualizations and Future Directions.Current oncology reports · 2022Review
- Prospective patient-reported symptom profiles associated with pediatric acute lymphoblastic leukemia relapse.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Cerebrospinal Fluid Metabolomic Profiles Associated With Fatigue During Treatment for Pediatric Acute Lymphoblastic Leukemia.Journal of pain and symptom management · 2021Article
- Feasibility and acceptability of a game-based symptom-reporting app for children with cancer: perspectives of children and parents.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life.Oncology nursing forum · 2019Article
- Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.Biological research for nursing · 2016Article
- Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia.Journal of pediatric hematology/oncology · 2015Article
- Symptoms in Children Receiving Treatment for Cancer-Part I: Fatigue, Sleep Disturbance, and Nausea/Vomiting.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesReview
- New Trends and Recent Care Approaches in Pediatric Oncology Nursing.Asia-Pacific journal of oncology nursingReview
- Symptoms, Physical Activity, and Biomarkers in Children at the End of Leukemia Maintenance Therapy.Journal of pediatric hematology/oncology nursingArticle
- Symptom Biomarkers for Children Receiving Treatment for Cancer: State of the Science.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesReview
- Symptoms in Children Receiving Treatment for Cancer-Part II: Pain, Sadness, and Symptom Clusters.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology NursesReview
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
PURPOSE/
objectivesTo explore the symptom trajectory during the first 16 months of childhood leukemia treatment and any associations with the oxidative stress pathway measured by cerebrospinal fluid (CSF) concentration of oxidized phosphatidylcholine (PC), the predominant glycerophospholipid in the brain and cell membranes.
designProspective, longitudinal design.
settingTwo cancer centers in the southwestern United States. SAMPLE: 36 children (aged 3-14 years) newly diagnosed with acute lymphoblastic leukemia.
methodsSymptoms were measured using the Memorial Symptom Assessment Scale at six specific time points during treatment. Biochemical changes in oxidative stress were measured by oxidized PC in the CSF. MAIN RESEARCH VARIABLES: Childhood cancer symptoms, oxidized PC.
findingsSignificant differences were found in the number of symptoms experienced during the three phases of treatment. Symptom trajectory changes and influence of the oxidative stress pathway on symptom experiences were identified.
conclusionsSymptoms experienced during treatment for childhood leukemia are associated with increased oxidative stress. IMPLICATIONS FOR NURSING: Children with leukemia experience symptoms throughout treatment. Physiologic measures indicate the influence of oxidative stress on symptoms.
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Registered trials
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