ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY.
Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Changes in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis.Obesity surgery · 2020Pooled it
- Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis.Obesity surgery · 2016Pooled it
- Trial
- Weight loss induced bone loss: mechanism of action and clinical implications.Bone research · 2025Review
- The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass.Bone · 2023Article
- Effects of bariatric surgery on drug pharmacokinetics-Preclinical studies.Frontiers in pharmacology · 2023Review
- Interrelationship between Vitamin D and Calcium in Obesity and Its Comorbid Conditions.Nutrients · 2022Review
- Bone Health after Bariatric Surgery: Consequences, Prevention, and Treatment.Advanced biomedical research · 2022Review
- Bone Metabolism in Adolescents Undergoing Bariatric Surgery.The Journal of clinical endocrinology and metabolism · 2021Review
- Roux-en-Y gastric bypass and gastric sleeve surgery result in long term bone loss.International journal of obesity (2005) · 2021Article
- Impact of sleeve gastrectomy on hip structural analysis in adolescents and young adults with obesity.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2020Article
- Article
- Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats.Frontiers in endocrinology · 2019Article
- Thin bones: Vitamin D and calcium handling after bariatric surgery.Bone reports · 2018Article
- Bone Health After Bariatric Surgery.JBMR plus · 2018Review
- Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties.Scientific reports · 2018Article
- Transgenic Expression of the Vitamin D Receptor Restricted to the Ileum, Cecum, and Colon of Vitamin D Receptor Knockout Mice Rescues Vitamin D Receptor-Dependent Rickets.Endocrinology · 2017Article
- Vitamin D and intestinal calcium transport after bariatric surgery.The Journal of steroid biochemistry and molecular biology · 2017Review
- Change in fracture risk and fracture pattern after bariatric surgery: nested case-control study.BMJ (Clinical research ed.) · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMetabolic bone disease and bariatric surgery have long been interconnected. The objective of this study is to better understand the mechanisms of bone mass loss after Roux-en-Y gastric bypass (RYGB) surgery. We evaluated mineral homeostasis and bone mass in diet-induced obese (DIO) rats after RYGB or sham surgery.
methodsTwelve DIO male Sprague Dawley rats underwent RYGB (n = 8) or sham (n = 4) surgery at 21 weeks of age. Postoperatively, animals ate an ad libitum 40% fat, normal calcium diet and were euthanized 22 weeks later. Serum and urine chemistries, insulin, leptin, bone turnover markers (BTM), and calciotropic and gut hormones were measured before and 22 weeks after surgery. Femurs were analyzed using microcomputed tomography (µCT).
resultsCompared to sham, RYGB animals had lower serum bicarbonate, calcium, 25-hydroxyvitamin D, insulin, and leptin levels with higher serum parathyroid hormone, peptide YY, and urinary calcium at 43 weeks of age. Sham control rats gained weight and had coupled decreases in formation (P1NP and OC) and unchanged resorption (CTX) BTMs. Comparatively, RYGB animals had higher serum CTX and OC but even lower P1NP levels than controls. µCT revealed lower trabecular bone volume, number, and thickness and lower cortical bone volume, thickness, and moment of inertia relative to controls.
conclusionIn rats with DIO, long-term RYGB-associated bone resorption appears to be driven in part by vitamin D malabsorption and secondary hyperparathyroidism. Other mechanisms, such as chronic acidosis, changes in fat-secreted hormones, and persistently elevated gut-derived hormone peptide YY, may also contribute to observed bone mass differences. Further investigation of these potential contributors to bone loss may lead to new targets for skeletal maintenance after RYGB.
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