ArticleThe British journal of radiology2014
Second brain tumors following central nervous system radiotherapy in childhood.
Article in The British journal of radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Radiation-induced meningiomas: A systematic review and meta-analysis of 927 meningiomas.Surgical neurology international · 2026Review
- Subsequent Meningiomas Among Survivors of Childhood Cancer.JAMA network open · 2025Article
- Development and validation of a machine learning-based survival prediction model for Asian glioblastoma patients using the SEER database and Chinese data.Scientific reports · 2025Article
- Second Primary Tumors After Primary Brain Tumors and Vice Versa: A Single-Center, Retrospective Study.Brain tumor research and treatment · 2025Article
- Impact of prior cancer history on survival in brain malignancy: A propensity score-adjusted, population-based study.Cancer reports (Hoboken, N.J.) · 2024Article
- Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas.Frontiers in oncology · 2024Review
- Risks of leukemia, intracranial tumours and lymphomas in childhood and early adulthood after pediatric radiation exposure from computed tomography.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Short and Long-Term Toxicity in Pediatric Cancer Treatment: Central Nervous System Damage.Cancers · 2022Review
- Review
- Characteristics and Outcomes of Second Malignant Neoplasms after Childhood Cancer Treatment: Multi-Center Retrospective Survey.Journal of Korean medical science · 2016Article
- Risk of Second Primary Neoplasms of the Central Nervous System.Advances in radiation oncologyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe second tumour (ST) occurrence is a relatively uncommon late complication of radiotherapy but represents one of the most significant issues, especially in childhood oncology. We describe our experience with patients who developed second brain neoplasm following cranial irradiation in childhood.
methodsWe identified nine patients who received radiotherapy owing to central nervous system tumour in childhood and subsequently developed the second brain tumour. The full clinical and radiological documentation and histopathological reports were reviewed. Risk factors such as age at irradiation, latency period to ST diagnosis, radiotherapy doses and volumes and other therapy methods were evaluated. We correlated the ST location with the three levels of irradiation dose (high, >40 Gy; medium, 25-40 Gy; and low <25 Gy).
resultsFive meningiomas and four gliomas occurred as the ST after the mean time of 11.7 years after radiotherapy. The average age of children during irradiation was 4.6 years. The shorter latency time to the ST induction was found in children treated with chemotherapy (9 years vs 17.2 years). Seven STs developed in the area of high and moderate dose (>25 Gy), only two low-grade gliomas appeared in the low-dose region.
conclusionOur data suggest that the STs usually develop in the brain tissues that received doses >25 Gy in patients irradiated at a young age. ADVANCES IN KNOWLEDGE: The low-dose volume seems not to be so significant for second brain neoplasm induction. Therefore, the modern intensity-modulated radiotherapy technique could be safely applied in paediatric patients.
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