Evidence map›Paper›PMID 24968389›Full record

SynthesisEnvironmental health perspectives2014

The Navigation Guide - evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth.

Juleen Lam, Erica Koustas, Patrice Sutton, Paula I Johnson, Dylan S Atchley, Saunak Sen, Karen A Robinson, Daniel A Axelrad, Tracey J Woodruff

Open access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 21 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 21 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. Public health evaluation of PFAS exposures and breastfeeding: a systematic literature review.Toxicological sciences : an official journal of the Society of Toxicology · 2023
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  11. Association between Exposure toEnvironmental health perspectives · 2017
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  14. A primer on systematic reviews in toxicology.Archives of toxicology · 2017
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Juleen LamOak Ridge Institute for Science and Education (ORISE) Postdoctoral Fellow, National Center for Environmental Economics, Office of Policy, U.S. Environmental Protection Agency, Washington, DC, USA.
Erica Koustas
Patrice Sutton
Paula I Johnson
Dylan S Atchley
Saunak Sen
Karen A Robinson
Daniel A Axelrad
Tracey J Woodruff
University of California, San Francisco · USEnvironmental Protection Agency · USJohns Hopkins University · US

Funding

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's CenterP01ES022841 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2018
$3.9M
Project 2: Assessing the Effects on BPA Exposure on Early Human DevelopmentP20ES018135 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2010 to 2012
$617k
NIEHS NIH HHS ES018135NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P20 ES018135PHS HHS ESO22841
6 · The paper itself

Abstract

backgroundThe Navigation Guide is a novel systematic review method to synthesize scientific evidence and reach strength of evidence conclusions for environmental health decision making.

objectiveOur aim was to integrate scientific findings from human and nonhuman studies to determine the overall strength of evidence for the question "Does developmental exposure to perfluorooctanoic acid (PFOA) affect fetal growth in humans?"

methodsWe developed and applied prespecified criteria to systematically and transparently a) rate the quality of the scientific evidence as "high," "moderate," or "low"; b) rate the strength of the human and nonhuman evidence separately as "sufficient," "limited," "moderate," or "evidence of lack of toxicity"; and c) integrate the strength of the human and nonhuman evidence ratings into a strength of the evidence conclusion.

resultsWe identified 18 epidemiology studies and 21 animal toxicology studies relevant to our study question. We rated both the human and nonhuman mammalian evidence as "moderate" quality and "sufficient" strength. Integration of these evidence ratings produced a final strength of evidence rating in which review authors concluded that PFOA is "known to be toxic" to human reproduction and development based on sufficient evidence of decreased fetal growth in both human and nonhuman mammalian species.

conclusionWe concluded that developmental exposure to PFOA adversely affects human health based on sufficient evidence of decreased fetal growth in both human and nonhuman mammalian species. The results of this case study demonstrate the application of a systematic and transparent methodology, via the Navigation Guide, for reaching strength of evidence conclusions in environmental health.

Indexed as

AnimalsBirth WeightCaprylatesEnvironmental HealthEnvironmental PollutantsEvidence-Based MedicineFemaleFetal DevelopmentFluorocarbonsHumansMaternal ExposurePregnancyCaprylatesEnvironmental PollutantsFluorocarbonsperfluorooctanoic acid

Identifiers

PMID24968389
PMCPMC4181930
OpenAlexW1987523543

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.