ArticleDevelopmental biology2014
Arx together with FoxA2, regulates Shh floor plate expression.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Dynamics of morphogen source formation in a growing tissue.PLoS computational biology · 2024Article
- Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging.Nature communications · 2024Article
- Gastrulation-stage gene expression inScience advances · 2024Article
- Mirk/Dyrk1B controls ventral spinal cord development via Shh pathway.Cellular and molecular life sciences : CMLS · 2024Article
- Cortical interneuron development is affected in 4H leukodystrophy.Brain : a journal of neurology · 2023Article
- Persistence of FoxJ1Cellular and molecular life sciences : CMLS · 2023Article
- From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson's Disease Modeling and Regenerative Therapy.International journal of molecular sciences · 2023Review
- Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies.Developmental cell · 2023Article
- Identification of microRNAs related with neural germ layer lineage-specific progenitors during reprogramming.Journal of molecular histology · 2022Article
- PIK3R2/Pik3r2 Activating Mutations Result in Brain Overgrowth and EEG Changes.Annals of neurology · 2020Article
- Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein.Bioscience reports · 2020Article
- Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos.Frontiers in neuroanatomy · 2020Article
- RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1Stem cell reports · 2019Article
- Arx Expression Suppresses Ventralization of the Developing Dorsal Forebrain.Scientific reports · 2019Article
- Negative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate.Frontiers in neuroscience · 2019Article
- Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells.Development (Cambridge, England) · 2018Article
- Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.Cell stem cell · 2018Article
- The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation.Aging and disease · 2017Review
- Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases.Cell reports · 2017Article
- Moving the Shh Source over Time: What Impact on Neural Cell Diversification in the Developing Spinal Cord?Journal of developmental biology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations in the Aristaless related homeodomain transcription factor (ARX) are associated with a diverse set of X-linked mental retardation and epilepsy syndromes in humans. Although most studies have been focused on its function in the forebrain, ARX is also expressed in other regions of the developing nervous system including the floor plate (FP) of the spinal cord where its function is incompletely understood. To investigate the role of Arx in the FP, we performed gain-of-function studies in the chick using in ovo electroporation, and loss-of-function studies in Arx-deficient mice. We have found that Arx, in conjunction with FoxA2, directly induces Sonic hedgehog (Shh) expression through binding to a Shh floor plate enhancer (SFPE2). We also observed that FoxA2 induces Arx through its transcriptional activation domain whereas Nkx2.2, induced by Shh, abolishes this induction. Our data support a feedback loop model for Arx function; through interactions with FoxA2, Arx positively regulates Shh expression in the FP, and Shh signaling in turn activates Nkx2.2, which suppresses Arx expression. Furthermore, our data are evidence that Arx plays a role as a context dependent transcriptional activator, rather than a primary inducer of Shh expression, potentially explaining how mutations in ARX are associated with diverse, and often subtle, defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.