ArticlePloS one2014
Influenza vaccination accelerates recovery of ferrets from lymphopenia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 27 citations in OpenAlex.
- Risk assessment of avian influenza A(H5N5) virus from the first human case using the ferret model.Journal of virology · 2026Article
- Polymeric nanoparticle-based mRNA vaccine is protective against influenza virus infection in ferrets.Molecular therapy. Nucleic acids · 2024Article
- Effects of Buprenorphine Treatment on Influenza Pathogenesis in the Ferret (Comparative medicine · 2022Article
- Influenza Virus Infects and Depletes Activated Adaptive Immune Responders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity.eLife · 2021Article
- Pathology and Immunity After SARS-CoV-2 Infection in Male Ferrets Is Affected by Age and Inoculation Route.Frontiers in immunology · 2021Article
- Immune Imprinting in the Influenza Ferret Model.Vaccines · 2020Review
- Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model.Translational research : the journal of laboratory and clinical medicine · 2020Article
- A Guide for the Use of the Ferret Model for Influenza Virus Infection.The American journal of pathology · 2020Review
- Improving immunological insights into the ferret model of human viral infectious disease.Influenza and other respiratory viruses · 2019Review
- Tropism and Infectivity of a Seasonal A(H1N1) and a Highly Pathogenic Avian A(H5N1) Influenza Virus in Primary Differentiated Ferret Nasal Epithelial Cell Cultures.Journal of virology · 2019Article
- Heterosubtypic cross-protection correlates with cross-reactive interferon-gamma-secreting lymphocytes in the ferret model of influenza.Scientific reports · 2019Article
- Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets.NPJ vaccines · 2019Article
- VOC breath profile in spontaneously breathing awake swine during Influenza A infection.Scientific reports · 2018Article
- Extensive T cell cross-reactivity between diverse seasonal influenza strains in the ferret model.Scientific reports · 2018Article
- Cellular immune response to human influenza viruses differs between H1N1 and H3N2 subtypes in the ferret lung.PloS one · 2018Article
- Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.Journal of immunological methods · 2017Article
- Generation of Monoclonal Antibodies against Immunoglobulin Proteins of the Domestic Ferret (Journal of immunology research · 2017Article
- Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection.Journal of virology · 2016Article
- Structural and functional characterisation of ferret interleukin-2.Developmental and comparative immunology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferrets are a useful animal model for human influenza virus infections, since they closely mimic the pathogenesis of influenza viruses observed in humans. However, a lack of reagents, especially for flow cytometry of immune cell subsets, has limited research in this model. Here we use a panel of primarily species cross-reactive antibodies to identify ferret T cells, cytotoxic T lymphocytes (CTL), B cells, and granulocytes in peripheral blood. Following infection with seasonal H3N2 or H1N1pdm09 influenza viruses, these cell types showed rapid and dramatic changes in frequency, even though clinically the infections were mild. The loss of B cells and CD4 and CD8 T cells, and the increase in neutrophils, were especially marked 1-2 days after infection, when about 90% of CD8+ T cells disappeared from the peripheral blood. The different virus strains led to different kinetics of leukocyte subset alterations. Vaccination with homologous vaccine reduced clinical symptoms slightly, but led to a much more rapid return to normal leukocyte parameters. Assessment of clinical symptoms may underestimate the effectiveness of influenza vaccine in restoring homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.