Trial reportChest2014
Decreased cough sensitivity and aspiration in Parkinson disease.
Trial report in Chest, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Upper Airway Sensory Testing in Dysphagia - Implications for Clinical Practice and Future Research Directions.Dysphagia · 2025Pooled it
- Pooled it
- Characterization of Ethyl Butyrate-Induced Cough Before and After Breath Control Techniques in Healthy Adults.American journal of speech-language pathology · 2023Trial
- Remifentanil requirement for i-gel insertion is reduced in male patients with Parkinson's disease undergoing deep brain stimulator implantation: an up-and-down sequential allocation trial.BMC anesthesiology · 2022Trial
- Pharmacokinetics, Pharmacodynamics, and Safety of Rasagiline Transdermal Patch: A Preliminary Study in Healthy Chinese Subjects.Clinical drug investigation · 2018Trial
- Neural mechanisms of cough: insights from multimodal magnetic resonance imaging-a narrative review.Journal of thoracic disease · 2026Review
- Body Fluid-based Biomarkers for Cognitive Impairment in Parkinson's Disease.Annals of neurosciences · 2026Review
- The prevalence of gastrointestinal dysfunction and its impact on quality of life in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Assessing Relationships Between Patient and Caregiver Reported Outcome Measures of Dysphagia in Parkinson Disease: A Retrospective Study.Dysphagia · 2026Article
- Characteristics of Swallowing Function in People with Parkinson's Disease: A Scoping Review.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Alpha-Synuclein Lesions in the Peripheral Nervous System of the Larynx in Parkinson's Disease.Dysphagia · 2026Article
- Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Improved oxygen saturation after deep brain stimulation in Parkinson's disease.Neurosurgical review · 2025Article
- Pan-Gut Dysmotility in Parkinson Disease.Gastroenterology & hepatology · 2025Article
- Dyspnea and dystussia in Parkinson's disease: patient-reported prevalence and determinants.Journal of neurology · 2025Article
- Effects of the continuous subcutaneous infusion of foslevodopa-foscarbidopa on swallowing in patients with Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Enhancing Cough Motor Learning in Parkinson's Disease Through Variable Practice During Skill Training.Movement disorders clinical practice · 2024Article
- Sensorimotor Cough Dysfunction in Cerebellar Ataxias.Cerebellum (London, England) · 2024Article
- Article
- Cough Correlates of Functional Swallow Outcomes in Atypical Parkinsonism.Movement disorders clinical practice · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAspiration pneumonia is a leading cause of death in people with Parkinson disease (PD). The pathogenesis of these infections is largely attributed to the presence of dysphagia with silent aspiration or aspiration without an appropriate cough response. The goal of this study was to test reflex cough thresholds and associated urge-to-cough (UTC) ratings in participants with PD with and without dysphagia.
methodsTwenty participants with PD were recruited for this study. They completed a capsaicin challenge with three randomized blocks of 0, 50, 100, and 200 μM capsaicin and rated their UTC by modified Borg scale. The concentration of capsaicin that elicited a two-cough response, total number of coughs, and sensitivity of the participant to the cough stimulus (UTC) were measured. The dysphagia severity of participants with PD was identified with the penetration-aspiration scale.
resultsMost participants with PD did not have a consistent two-cough response to 200 μM capsaicin. UTC ratings and total number of coughs produced at 200 μM capsaicin were significantly influenced by dysphagia severity but not by general PD severity, age, or disease duration. Increasing levels of dysphagia severity resulted in significantly blunted cough sensitivity (UTC).
conclusionsUTC ratings may be important in understanding the mechanism underlying morbidity related to aspiration pneumonia in people with PD and dysphagia. Further understanding of decreased UTC in people with PD and dysphagia will be essential for the development of strategies and treatments to address airway protection deficits in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.