ArticlePLoS genetics2014
BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals.Nature communications · 2026Article
- Genome-wide characterization of theFrontiers in plant science · 2026Article
- Somatic gonad morphogenesis in C. elegans requires the heterochronic pathway acting through HBL-1.G3 (Bethesda, Md.) · 2025Article
- MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans.PLoS genetics · 2025Article
- FLYWCH transcription factors act in a LIN-42/Period autoregulatory loop during gonad migration inbioRxiv : the preprint server for biology · 2025Article
- Article
- Accessible Region Conformation Capture (ARC-C) gives high-resolution insights into genome architecture and regulation.Genome research · 2022Article
- Modelling themicroPublication biology · 2022Article
- BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription.Development (Cambridge, England) · 2021Article
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
- Conserved and Unique Functions of Blimp1 in Immune Cells.Frontiers in immunology · 2021Review
- Article
- Regulation ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response.PLoS biology · 2019Article
- Functional Annotation ofBiomolecules · 2018Article
- Invading, Leading and Navigating Cells inGenetics · 2018Review
- Regulating distal tip cell migration in space and time.Mechanisms of development · 2017Review
- Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion.Scientific reports · 2017Article
- BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans.Genetics · 2016Article
- Noise propagation with interlinked feed-forward pathways.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatiotemporal regulation of cell migration is crucial for animal development and organogenesis. Compared to spatial signals, little is known about temporal signals and the mechanisms integrating the two. In the Caenorhabditis elegans hermaphrodite, the stereotyped migration pattern of two somatic distal tip cells (DTCs) is responsible for shaping the gonad. Guidance receptor UNC-5 is necessary for the dorsalward migration of DTCs. We found that BLMP-1, similar to the mammalian zinc finger transcription repressor Blimp-1/PRDI-BF1, prevents precocious dorsalward turning by inhibiting precocious unc-5 transcription and is only expressed in DTCs before they make the dorsalward turn. Constitutive expression of blmp-1 when BLMP-1 would normally disappear delays unc-5 transcription and causes turn retardation, demonstrating the functional significance of blmp-1 down-regulation. Correct timing of BLMP-1 down-regulation is redundantly regulated by heterochronic genes daf-12, lin-29, and dre-1, which regulate the temporal fates of various tissues. DAF-12, a steroid hormone receptor, and LIN-29, a zinc finger transcription factor, repress blmp-1 transcription, while DRE-1, the F-Box protein of an SCF ubiquitin ligase complex, binds to BLMP-1 and promotes its degradation. We have therefore identified a gene circuit that integrates the temporal and spatial signals and coordinates with overall development of the organism to direct cell migration during organogenesis. The tumor suppressor gene product FBXO11 (human DRE-1 ortholog) also binds to PRDI-BF1 in human cell cultures. Our data suggest evolutionary conservation of these interactions and underscore the importance of DRE-1/FBXO11-mediated BLMP-1/PRDI-BF1 degradation in cellular state transitions during metazoan development.
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