ArticleThe journal of physical chemistry. B2014
Structure and properties of DNA in apolar solvents.
Article in The journal of physical chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Rapid Apta-Chromogenic Detection Method for Nitrofuran Metabolite Determination.Molecules (Basel, Switzerland) · 2024Article
- Article
- Effects of solvent-based adhesive removal on the subsequent dual analysis of fingerprint and DNA.International journal of legal medicine · 2023Article
- Development of an Automatable Affinity Purification Process for DNA-Encoded Chemistry.ACS omega · 2022Article
- Multifrequency Investigation of Single- and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors.Biosensors · 2022Article
- DNA recovery after sequential processing of latent fingerprints on copy paper.Journal of forensic sciences · 2022Article
- Synthetic Elaboration of Native DNA by RASS (SENDR).ACS central science · 2020Article
- Article
- Long-timescale dynamics of the Drew-Dickerson dodecamer.Nucleic acids research · 2016Article
- The structural stability and catalytic activity of DNA and RNA oligonucleotides in the presence of organic solvents.Biophysical reviews · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The study of nucleic acids in low-polarity environments paves the way for novel biotechnological applications of DNA. Here, we use a repertoire of atomistic molecular simulation tools to study the nature of DNA when placed in a highly apolar environment and when transferred from aqueous to apolar solvent. Our results show that DNA becomes stiffer in apolar solvents and suggest that highly negatively charged states, which are the most prevalent in water, are strongly disfavored in apolar solvents and neutral states with conformations not far from the aqueous ones are the dominant forms. Transfer from water to an apolar solvent such as CCl4 is unlikely to occur, but our results suggest that if forced, the DNA would migrate surrounded by a small shell of water (the higher the DNA charge, the larger the number of water molecules in this shell). Even the neutral form (predicted to be the dominant one in apolar solvents) would surround itself by a small number of highly stable water molecules when moved from water to a highly apolar environment. Neutralization of DNA charges seems a crucial requirement for transfer of DNA to apolar media, and the most likely mechanism to achieve good transfer properties.
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Registered trials
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