ArticlePloS one2014
Optically measured microvascular blood flow contrast of malignant breast tumors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06360809 (Prehabilitation Exercise Program in Breast Cancer), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prehabilitation Exercise Program in Breast Cancer: Effects on Quality of Life and Tumor Microenvironment (PEP_BC)
Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Discriminating Breast Cancer Patients by Spectral Analysis of Arterial Pulse Waveforms.Cardiovascular engineering and technology · 2026Article
- Pulse wave analysis for quality-of-life associated early physiological changes during breast cancer chemotherapy: a proof-of-concept pilot study.The oncologist · 2026Observational
- AI-assisted diffuse correlation tomography for identifying breast cancer.Journal of biomedical optics · 2025Article
- Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy.Neurophotonics · 2025Article
- Diffuse correlation tomography: a technique to characterize tissue blood flow abnormalities in benign and malignant breast lesions.Biomedical optics express · 2024Article
- A Device-on-Chip Solution for Real-Time Diffuse Correlation Spectroscopy Using FPGA.Biosensors · 2024Article
- Hemoglobin signal network mapping reveals novel indicators for precision medicine.Scientific reports · 2023Article
- Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy.Breast cancer research : BCR · 2023Article
- Non-invasive low-cost deep tissue blood flow measurement with integrated Diffuse Speckle Contrast Spectroscopy.Frontiers in neuroergonomics · 2023Article
- Collimating micro-lens fiber array for noncontact near-infrared diffuse correlation tomography.Biomedical optics express · 2021Article
- Enhancement of diffuse correlation spectroscopy tissue blood flow measurement by acoustic radiation force.Biomedical optics express · 2020Article
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Approaches to denoise the diffuse optical signals for tissue blood flow measurement.Biomedical optics express · 2018Article
- Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging.Journal of biomedical optics · 2018Article
- Laser safety in fiber-optic monitoring of spinal cord hemodynamics: a preclinical evaluation.Journal of biomedical optics · 2018Article
- Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy.Physics in medicine and biology · 2017Article
- Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics.Biomedical optics express · 2017Article
- Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging.Physiological measurement · 2017Review
- Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy.Journal of biomedical optics · 2017Article
- Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest.Biomedical optics express · 2016Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Microvascular blood flow contrast is an important hemodynamic and metabolic parameter with potential to enhance in vivo breast cancer detection and therapy monitoring. Here we report on non-invasive line-scan measurements of malignant breast tumors with a hand-held optical probe in the remission geometry. The probe employs diffuse correlation spectroscopy (DCS), a near-infrared optical method that quantifies deep tissue microvascular blood flow. Tumor-to-normal perfusion ratios are derived from thirty-two human subjects. Mean (95% confidence interval) tumor-to-normal ratio using surrounding normal tissue was 2.25 (1.92-2.63); tumor-to-normal ratio using normal tissues at the corresponding tumor location in the contralateral breast was 2.27 (1.94-2.66), and using normal tissue in the contralateral breast was 2.27 (1.90-2.70). Thus, the mean tumor-to-normal ratios were significantly different from unity irrespective of the normal tissue chosen, implying that tumors have significantly higher blood flow than normal tissues. Therefore, the study demonstrates existence of breast cancer contrast in blood flow measured by DCS. The new, optically accessible cancer contrast holds potential for cancer detection and therapy monitoring applications, and it is likely to be especially useful when combined with diffuse optical spectroscopy/tomography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.