ArticleBritish journal of cancer2014
Nomogram to predict ypN status after chemoradiation in patients with locally advanced rectal cancer.
Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Nomograms for colorectal cancer: A systematic review.World journal of gastroenterology · 2015Pooled it
- Prognostic significance of clinical and pathological stages on locally advanced rectal carcinoma after neoadjuvant chemoradiotherapy.Radiation oncology (London, England) · 2015Trial
- Multiparametric MRI with pea pod sign and muscularis propria striped enhancement improves T2 vs T3a-b rectal cancer staging accuracy.European radiology · 2026Article
- A nomogram for predicting good response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer: a retrospective, double-center, cohort study.International journal of colorectal disease · 2022Article
- Lymph node regression grading of locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy.World journal of gastrointestinal oncology · 2022Review
- Nomogram predicting cancer-specific mortality in early-onset rectal cancer: a competing risk analysis.International journal of colorectal disease · 2020Article
- Nomogram for prediction of pathologic complete remission using biomarker expression and endoscopic finding after preoperative chemoradiotherapy in rectal cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Prediction of tumor response of rectal cancer cells via 3D cell culture andOncology letters · 2019Article
- Radiomics analysis of multiparametric MRI for prediction of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.European radiology · 2019Article
- Nomogram for predicting anastomotic leakage after low anterior resection for rectal cancer.International journal of colorectal disease · 2018Article
- Perineural Invasion Predicts for Distant Metastasis in Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemoradiation and Surgery.American journal of clinical oncology · 2017Article
- Article
- Clinical utility of pretreatment prediction of chemoradiotherapy response in rectal cancer: a review.The EPMA journal · 2017Review
- Long-Term Outcome of Rectal Cancer With Clinically (EUS/MRI) Metastatic Mesorectal Lymph Nodes Treated by Neoadjuvant Chemoradiation: Role of Organ Preservation Strategies in Relation to Pathologic Response.Annals of surgical oncology · 2016Article
- Prognostic significance of pathological response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer.International journal of clinical oncology · 2016Article
- New Perspectives on Predictive Biomarkers of Tumor Response and Their Clinical Application in Preoperative Chemoradiation Therapy for Rectal Cancer.Yonsei medical journal · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPelvic lymph node (LN) status after preoperative chemoradiotherapy (CRT) is an important indicator of oncologic outcome in patients with locally advanced rectal cancer. The purpose of this study was to develop a nomogram to predict LN status after preoperative CRT in locally advanced rectal cancer patients.
methodsThe nomogram was developed in a training cohort (n=891) using logistic regression analyses and validated in a validation cohort (n=258) from a prospectively registered tumour registry at Asan Medical Center. The model was internally and externally validated for discrimination and calibration using bootstrap resampling. Model performance was evaluated by the concordance index (c-index) and calibration curve.
resultsPretreatment ypT stage, patient age, preCRT tumour differentiation, cN stage, lymphovascular invasion, and perineural invasion were reliable predictors of LN metastasis after preoperative CRT. The nomogram developed using these parameters had c-indices of 0.81 (training) and 0.77 (validation). The calibration plot suggested good agreement between actual and nomogram-predicted LN status after preoperative CRT.
conclusionsThis nomogram improves prediction of LN status after preoperative CRT in patients with locally advanced rectal cancer. It will be useful for counselling patients as well as for the design and stratification of patients in clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.