Evidence map›Paper›PMID 24967870›Full record

ArticlePharmacology, biochemistry, and behavior2014

Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.

Deanne M Buffalari, Nana Yaa A Marfo, Tracy T Smith, Melissa E Levin, Matthew T Weaver, Edda Thiels, Alan F Sved, Eric C Donny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Nicotine Enhances Intravenous Self-administration of Cannabinoids in Adult Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Nicotine Enhances Footshock- and Lithium Chloride-Conditioned Place Avoidance in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016
    Article
  15. Effects of Monoamine Oxidase Inhibition on the Reinforcing Properties of Low-Dose Nicotine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Deanne M BuffalariDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: deanne@pitt.edu.
Nana Yaa A MarfoDepartment of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Tracy T SmithDepartment of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Melissa E LevinDepartment of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Matthew T WeaverDepartment of Psychology, Mercyhurst University, Erie, PA 16546, USA.
Edda ThielsDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Alan F SvedDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Eric C DonnyDepartment of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.
University of Pittsburgh · USMercyhurst University · US

Funding

SELF ADMINISTERED VS NONCONTINGENT NICOTINER01DA010464 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONNY, ERIC CHRISTIAN · 1997 to 2012
$3.5M
NIDA NIH HHS R01 DA010464
6 · The paper itself

Abstract

Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. The animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.

Indexed as

Conditioning, ClassicalAnimalsCocaineMaleNicotineRatsRats, Sprague-DawleySucroseCocaineNicotineSucroseCocaineConditioned place preferenceEnhancementNicotineReinforcementSucrose

Identifiers

PMID24967870
PMCPMC4527043
OpenAlexW2085266782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.