ArticlePloS one2014
Molecular epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus bloodstream isolates in Taiwan, 2010.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Insight into the Clonal Lineage and Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Molecular characterization and virulence gene profiling of methicillin-resistantFrontiers in microbiology · 2022Article
- Detection, spread and phylogeny of meticillin-resistantMicrobial genomics · 2021Article
- High prevalence nasal carriage of methicillin-resistantInfection prevention in practice · 2021Article
- Evolution and Population Structures of Prevalent Methicillin-ResistantFrontiers in microbiology · 2021Article
- Molecular Epidemiological Survey of Prophages in MRSA Isolates in Taiwan.Infection and drug resistance · 2020Article
- Evolution of Multi-Resistance to Vancomycin, Daptomycin, and Linezolid in Methicillin-ResistantFrontiers in microbiology · 2020Article
- Article
- Molecular characteristics and clinical features of pediatric methicillin-susceptible Staphylococcus aureus infection in a medical center in northern Taiwan.BMC infectious diseases · 2019Article
- Molecular typing revealed the emergence ofInfection and drug resistance · 2019Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Distribution ofInfection and drug resistance · 2018Article
- A 5-year Survey Reveals Increased Susceptibility to Glycopeptides for Methicillin-ResistantFrontiers in microbiology · 2017Article
- Novel Structure of Enterococcus faecium-Originated ermB-Positive Tn1546-Like Element in Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2016Article
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The information of molecular characteristics and antimicrobial susceptibility pattern of methicillin-resistant Staphylococcus aureus (MRSA) is essential for control and treatment of diseases caused by this medically important pathogen. A total of 577 clinical MRSA bloodstream isolates from six major hospitals in Taiwan were determined for molecular types, carriage of Panton-Valentine leukocidin (PVL) and sasX genes and susceptibilities to 9 non-beta-lactam antimicrobial agents. A total of 17 genotypes were identified in 577 strains by pulsotyping. Five major pulsotypes, which included type A (26.2%, belonging to sequence type (ST) 239, carrying type III staphylococcal chromosomal cassette mec (SCCmec), type F (18.9%, ST5-SCCmecII), type C (18.5%, ST59-SCCmecIV), type B (12.0%, ST239-SCCmecIII) and type D (10.9%, ST59-SCCmecVT/IV), prevailed in each of the six sampled hospitals. PVL and sasX genes were respectively carried by ST59-type D strains and ST239 strains with high frequencies (93.7% and 99.1%, respectively) but rarely detected in strains of other genotypes. Isolates of different genotypes and from different hospitals exhibited distinct antibiograms. Multi-resistance to ≥3 non-beta-lactams was more common in ST239 isolates (100%) than in ST5 isolates (97.2%, P = 0.0347) and ST59 isolates (8.2%, P<0.0001). Multivariate analysis further indicated that the genotype, but not the hospital, was an independent factor associated with muti-resistance of the MRSA strains. In conclusion, five common MRSA clones with distinct antibiograms prevailed in the major hospitals in Taiwan in 2010. The antimicrobial susceptibility pattern of invasive MRSA was mainly determined by the clonal distribution.
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