Evidence map›Paper›PMID 24967813›Full record

Trial reportPloS one2014

Maternal vitamin D status and infant outcomes in rural Vietnam: a prospective cohort study.

Sarah Hanieh, Tran T Ha, Julie A Simpson, Tran T Thuy, Nguyen C Khuong, Dang D Thoang, Thach D Tran, Tran Tuan, Jane Fisher, Beverley-Ann Biggs

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 7 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 7 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Sarah HaniehDepartment of Medicine, Melbourne Academic Centre, University of Melbourne at the Doherty Institute, Parkville, Victoria, Australia.
Tran T HaResearch and Training Centre for Community Development (RTCCD), Hanoi, Vietnam.
Julie A SimpsonCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.
Tran T ThuyResearch and Training Centre for Community Development (RTCCD), Hanoi, Vietnam.
Nguyen C KhuongProvincial Centre of Preventive Medicine, Hanam, Hanam Province, Vietnam.
Dang D ThoangProvincial Centre of Preventive Medicine, Hanam, Hanam Province, Vietnam.
Thach D TranResearch and Training Centre for Community Development (RTCCD), Hanoi, Vietnam; The Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
Tran TuanResearch and Training Centre for Community Development (RTCCD), Hanoi, Vietnam.
Jane FisherThe Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
Beverley-Ann BiggsDepartment of Medicine, Melbourne Academic Centre, University of Melbourne at the Doherty Institute, Parkville, Victoria, Australia; The Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Center for Environment and Community Assets Development · VNGeneral Department of Preventive Medicine · VNUniversity of Melbourne · AUJean Hailes · AUMonash University · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVitamin D deficiency affects 1 billion people globally. It has an important role in bone homeostasis, brain development and modulation of the immune system and yet the impact of antenatal vitamin D deficiency on infant outcomes is poorly understood. We assessed the association of 25- hydroxyvitamin D levels (25-OHD) in late pregnancy and early infant growth and developmental outcomes in rural Vietnam. DESIGN AND

methodsA prospective cohort study of 960 women who had previously participated in a double-blind cluster randomized controlled trial of antenatal micronutrient supplementation in rural Vietnam was undertaken. Maternal 25-OHD concentration was measured at 32 weeks gestation, and infants were followed until 6 months of age. Main outcome measures were cognitive, motor, socio-emotional and language scores using the Bayley Scales of Infant Development, 3rd edition, and infant length-for-age z scores at 6 months of age.

results60% (582/960) of women had 25-OHD levels <75 nmol/L at 32 weeks gestation. Infants born to women with 25-OHD deficiency (<37.5 nmol/L) had reduced developmental language scores compared to those born to women who were vitamin D replete (≥75 nmol/L) (Mean Difference (MD) -3.48, 95% Confidence Interval (CI) -5.67 to -1.28). For every 25 nmol increase in 25-OHD concentration in late pregnancy, infant length-for-age z scores at 6 months of age decreased by 0.08 (95% CI -0.15 to -0.02).

conclusionsLow maternal 25- hydroxyvitamin D levels during late pregnancy are of concern in rural Vietnam, and are associated with reduced language developmental outcomes at 6 months of age. Our findings strengthen the evidence for giving vitamin D supplementation during pregnancy.

Indexed as

Child DevelopmentRural Population25-Hydroxyvitamin D 2AdultDietary SupplementsFemaleHumansInfant, NewbornMalePregnancyVietnamVitamin DVitamin D Deficiency25-Hydroxyvitamin D 2Vitamin D

Identifiers

PMID24967813
PMCPMC4072587
OpenAlexW2073609709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.