ArticlePloS one2014
How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Psychological interventions for interoception in mental health disorders: A systematic review of randomized-controlled trials.Psychiatry and clinical neurosciences · 2023Pooled it
- Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Pooled it
- The Mind From Within: Visceral Roots of Human Cognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dissociative experiences and self-reported interoceptive traits in maladaptive daydreamers: a network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Comparison of three behavioral cardioception tasks and heartbeat evoked potentials in the same group of healthy volunteers.Scientific reports · 2025Article
- It Is Movement All the Way Down: Broken Rhythms and Embodied Selfhood in Depersonalization.Behavioral sciences (Basel, Switzerland) · 2025Article
- Trait dissociation is associated with dissociative experiences arising from disrupted multisensory integration.Scientific reports · 2025Article
- Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis.BMC psychiatry · 2024Article
- Profiles of intuitive eating in adults: the role of self-esteem, interoceptive awareness, and motivation for healthy eating.BMC psychiatry · 2024Article
- Examining the association between depersonalisation traits and the bodily self in waking and dreaming.Scientific reports · 2024Article
- Heart activity perception: narrative review on the measures of the cardiac perceptual ability.Biologia futura · 2024Review
- Neurophysiological changes associated with vibroacoustically-augmented breath-focused mindfulness for dissociation: targeting interoception and attention.Psychological medicine · 2023Article
- Touching and being touched: where knowing and feeling meet.Frontiers in psychology · 2023Article
- An Experimental Study of Subliminal Self-Face Processing in Depersonalization-Derealization Disorder.Brain sciences · 2022Article
- The inside of me: interoceptive constraints on the concept of self in neuroscience and clinical psychology.Psychological research · 2022Review
- The relationship between interoception and agency and its modulation by heartbeats: an exploratory study.Scientific reports · 2022Article
- Self, Me and I in the repertoire of spontaneously occurring altered states of Selfhood: eight neurophenomenological case study reports.Cognitive neurodynamics · 2022Article
- An action-concept processing advantage in a patient with a double motor cortex.Brain and cognition · 2022Article
- Brain Neural Underpinnings of Interoception and Decision-Making in Alzheimer's Disease: A Narrative Review.Frontiers in neuroscience · 2022Review
- The effects of subliminal or supraliminal sadness induction on the sense of body ownership and the role of dissociative symptoms.Scientific reports · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception -defined as the cognitive processing of body signals- has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient's impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.