ArticlePLoS genetics2014
Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Identification of CRF89_BF, a new member of an HIV-1 circulating BF intersubtype recombinant form family widely spread in South America.Scientific reports · 2021Trial
- Current and historic HIV-1 molecular epidemiology in paediatric and adult population from Kinshasa in the Democratic Republic of Congo.Scientific reports · 2020Trial
- Evolutionary dynamics of HIV-1 recombinants: analysis of contemporary and historical viral populations in East Africa.Virology journal · 2026Article
- Article
- Substantial deceleration of adaptation of HIV-1 within 1500 generations in an experimental evolution: a genomic perspective.Virus evolution · 2026Article
- Estimates of HIV-1 within-host recombination rates across the whole genome.Virus evolution · 2025Article
- Experimental Evolution Studies in Φ6 Cystovirus.Viruses · 2024Review
- Article
- Identification of a HIV-1 circulating BF1 recombinant form (CRF75_BF1) of Brazilian origin that also circulates in Southwestern Europe.Frontiers in microbiology · 2023Article
- Recombination smooths the time signal disrupted by latency in within-host HIV phylogenies.Virus evolution · 2023Article
- Conflicting effects of recombination on the evolvability and robustness in neutrally evolving populations.PLoS computational biology · 2022Review
- Article
- Becoming a Selfish Clan: Recombination Associated to Reverse-Transcription in LTR Retrotransposons.Genome biology and evolution · 2019Review
- Recombination and mutational robustness in neutral fitness landscapes.PLoS computational biology · 2019Article
- Article
- Recombination drives the evolution of mutational robustness.Current opinion in systems biology · 2019Article
- Article
- Recombination and peak jumping.PloS one · 2018Article
- A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project.PloS one · 2018Article
- Impact of Clinical Parameters in the Intrahost Evolution of HIV-1 Subtype B in Pediatric Patients: A Machine Learning Approach.Genome biology and evolution · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation on a large-scale empirical fitness landscape in HIV-1 based on in vitro fitness measurements. Our results indicate that recombination substantially increases the rate of adaptation under a wide range of parameter values for population size, mutation rate and recombination rate. The accelerating effect of recombination is stronger for intermediate mutation rates but increases in a monotonic way with the recombination rates and population sizes that we examined. We also found that both fitness effects of individual mutations and epistatic fitness interactions cause recombination to accelerate adaptation. The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I.
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