ArticlePloS one2014
Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Review
- Article
- Assessing developmental toxicity and non-CYP mediated biotransformation of two anti-epileptics and their human metabolites in zebrafish embryos and larvae.Current research in toxicology · 2024Article
- The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and COAntioxidants (Basel, Switzerland) · 2022Article
- The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis.Virchows Archiv : an international journal of pathology · 2021Article
- TLRs in Mycobacterial Pathogenesis: Black and White or Shades of Gray.Current microbiology · 2021Review
- Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.Frontiers in immunology · 2021Review
- Hif-1alpha stabilisation is protective against infection in zebrafish comorbid models.The FEBS journal · 2020Article
- Chemokine Receptors and Phagocyte Biology in Zebrafish.Frontiers in immunology · 2020Review
- Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe.Chemical science · 2019Article
- Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Hypoxia Induces MacrophageFrontiers in immunology · 2019Article
- Article
- Neutrophils use superoxide to control bacterial infection at a distance.PLoS pathogens · 2018Article
- Priming of innate antimycobacterial immunity by heat-killedDisease models & mechanisms · 2018Article
- Mechanisms of Fish Macrophage Antimicrobial Immunity.Frontiers in immunology · 2018Review
- A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.Cell · 2017Article
- Protection and pathology in TB: learning from the zebrafish model.Seminars in immunopathology · 2016Review
- The Zebrafish Breathes New Life into the Study of Tuberculosis.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary tuberculosis (TB), caused by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb), is a major world health problem. The production of reactive nitrogen species (RNS) is a potent cytostatic and cytotoxic defense mechanism against intracellular pathogens. Nevertheless, the protective role of RNS during Mtb infection remains controversial. Here we use an anti-nitrotyrosine antibody as a readout to study nitration output by the zebrafish host during early mycobacterial pathogenesis. We found that recognition of Mycobacterium marinum, a close relative of Mtb, was sufficient to induce a nitrosative defense mechanism in a manner dependent on MyD88, the central adaptor protein in Toll like receptor (TLR) mediated pathogen recognition. However, this host response was attenuated by mycobacteria via a virulence mechanism independent of the well-characterized RD1 virulence locus. Our results indicate a mechanism of pathogenic mycobacteria to circumvent host defense in vivo. Shifting the balance of host-pathogen interactions in favor of the host by targeting this virulence mechanism may help to alleviate the problem of infection with Mtb strains that are resistant to multiple drug treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.