ArticleNature communications2014
Natural occurring epialleles determine vitamin E accumulation in tomato fruits.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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98 citing papers in PubMed.
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- What metabolomics has taught us about tomato fruit ripening and quality.Journal of experimental botany · 2025Review
- Epigenetic control of the plant metabolome: implications for Chinese medicine.Chinese medicine · 2025Article
- Gene body methylation regulates gene expression and mediates phenotypic diversity in natural Arabidopsis populations.Nature plants · 2025Article
- Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance.The plant genome · 2025Review
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Molecular characterization of homogentisate phytyltransferase and methylphytylbenzoquinol methyltransferase genes from olive fruit with regard to the tocopherol content and the response to abiotic stresses.Frontiers in plant science · 2025Article
- Review
- Ectopic enhancer-enhancer interactions as causal forces driving RNA-directed DNA methylation in gene regulatory regions.Plant biotechnology journal · 2024Article
- Transgenerational epigenetic inheritance during plant evolution and breeding.Trends in plant science · 2024Review
- Analysis of the Mechanism of Wood Vinegar and Butyrolactone Promoting Rapeseed Growth and Improving Low-Temperature Stress Resistance Based on Transcriptome and Metabolomics.International journal of molecular sciences · 2024Article
- Heterologous Expression of SunflowerPlants (Basel, Switzerland) · 2024Article
- Deleterious mutation/epimutation-selection balance with and without inbreeding: a population (epi)genetics model.Genetics · 2024Article
- DNA methylation variations underlie lettuce domestication and divergence.Genome biology · 2024Article
- Uncovering DNA methylation landscapes to decipher evolutionary footprints of phenotypic diversity in chickpea.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Drought Responses in Poaceae: Exploring the Core Components of the ABA Signaling Pathway inPlants (Basel, Switzerland) · 2024Article
- Two adjacent NLR genes conferring quantitative resistance to clubroot disease in Arabidopsis are regulated by a stably inherited epiallelic variation.Plant communications · 2024Article
- Genotypic variation of tocopherol content in a representative genetic population and genome-wide association study on tocopherol in rapeseed (Molecular breeding : new strategies in plant improvement · 2023Article
38 more citing papers are in PubMed but not listed here.
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Abstract
Vitamin E (VTE) content is a low heritability nutritional trait for which the genetic determinants are poorly understood. Here, we focus on a previously detected major tomato VTE quantitative trait loci (QTL; mQTL(9-2-6)) and identify the causal gene as one encoding a 2-methyl-6-phytylquinol methyltransferase (namely VTE3(1)) that catalyses one of the final steps in the biosynthesis of γ- and α-tocopherols, which are the main forms of VTE. By reverse genetic approaches, expression analyses, siRNA profiling and DNA methylation assays, we demonstrate that mQTL(9-2-6) is an expression QTL associated with differential methylation of a SINE retrotransposon located in the promoter region of VTE3(1). Promoter DNA methylation can be spontaneously reverted leading to different epialleles affecting VTE3(1) expression and VTE content in fruits. These findings indicate therefore that naturally occurring epialleles are responsible for regulation of a nutritionally important metabolic QTL and provide direct evidence of a role for epigenetics in the determination of agronomic traits.
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