Trial reportBioMed research international2014
Differential effects of dry eye disorders on metabolomic profile by 1H nuclear magnetic resonance spectroscopy.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis.Bioactive materials · 2027Article
- Serum Glutamate in Dry Eye Disease: Associations with Symptoms and Clinical Signs.Diagnostics (Basel, Switzerland) · 2026Article
- Efficacy and Safety of Plasma Rich in Growth Factor in Patients with Congenital Aniridia and Dry Eye Disease.Diseases (Basel, Switzerland) · 2024Article
- The Plight of the Metabolite: Oxidative Stress and Tear Film Destabilisation Evident in Ocular Allergy Sufferers across Seasons in Victoria, Australia.International journal of molecular sciences · 2024Article
- A Review on Dry Eye Disease Treatment: Recent Progress, Diagnostics, and Future Perspectives.Pharmaceutics · 2023Review
- Candidate Molecular Compounds as Potential Indicators for Meibomian Gland Dysfunction.Frontiers in medicine · 2022Review
- Searching for the Antioxidant, Anti-Inflammatory, and Neuroprotective Potential of Natural Food and Nutritional Supplements for Ocular Health in the Mediterranean Population.Foods (Basel, Switzerland) · 2021Review
- Association between tear and blood glucose concentrations: Random intercept model adjusted with confounders in tear samples negative for occult blood.Journal of diabetes investigation · 2021Observational
- A Set of Global Metabolomic Biomarker Candidates to Predict the Risk of Dry Eye Disease.Frontiers in cell and developmental biology · 2020Article
- Analysis of amino acids in human tears by hydrophilic interaction liquid chromatography and quadrupole orbitrap mass spectrometry.RSC advances · 2019Article
- Tear Metabolomics in Dry Eye Disease: A Review.International journal of molecular sciences · 2019Review
- Using NMR in saliva to identify possible biomarkers of glioblastoma and chronic periodontitis.PloS one · 2018Article
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.Ophthalmology · 2017Article
- LC-MS-Based Metabolic Fingerprinting of Aqueous Humor.Journal of analytical methods in chemistry · 2017Article
- Tear fluid biomarkers in ocular and systemic disease: potential use for predictive, preventive and personalised medicine.The EPMA journal · 2016Review
- Ocular Surface and Tear Film Changes in Older Women Working with Computers.BioMed research international · 2015Article
- The alterations of ocular surface metabolism and the related immunity inflammation in dry eye.Advances in ophthalmology practice and researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used (1)H NMR spectroscopy to analyze the metabolomic profile of reflex tears from patients with dry eye disorders (DEDs). 90 subjects were divided into 2 groups: (1) patients with DEDs (DEDG; n = 55) and (2) healthy subjects (CG; n = 35). Additionally, the DEDG was subdivided into 2 subgroups based on DED severity: mild-to-moderate and moderate (n = 22 and n = 33, resp.). Personal interviews and systematized ophthalmologic examinations were carried out. Reflex tears (20-30 μL) were collected by gently rubbing in the inferior meniscus of both eyelids with a microglass pipette and stored at -80°C until analysis. NMR spectra were acquired using a standard one-dimensional pulse sequence with water suppression. Data were processed and transferred to MATLAB for further chemometric analysis. Main differences in tear composition between DEDG and CG were found in cholesterol, N-acetylglucosamine, glutamate, creatine, amino-n-butyrate, choline, acetylcholine, arginine, phosphoethanolamine, glucose, and phenylalanine levels. This metabolic fingerprint helped also to discriminate between the three additional subgroups of DEDG. Our results suggest that tear metabolic differences between DEDG and CG identified by NMR could be useful in understanding ocular surface pathogenesis and improving biotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.