Trial reportBioMed research international2014
Human aqueous humor levels of TGF- β2: relationship with axial length.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Relationship between Axial Length and Levels of TGF-BioMed research international · 2021Trial
- Aqueous Humour Cytokines as Predictors of Axial Elongation in High Myopia: A 2-Year Longitudinal Cohort Study.Clinical & experimental ophthalmology · 2026Observational
- Surgical outcomes of Ahmed valve implantation with mitomycin C in glaucoma with and without high myopia.BMC ophthalmology · 2025Article
- Comparison of trabeculectomy and gonioscopy-assisted transluminal trabeculotomy results in long eyes wıth open-angle glaucoma.International ophthalmology · 2025Article
- Congenital microcoria deletion in mouse links Sox21 dysregulation to disease and suggests a role for TGFB2 in glaucoma and myopia.American journal of human genetics · 2024Article
- Innate immune responsive inflammation in development of progressive myopia.Eye (London, England) · 2024Article
- Factors Correlated With Mid-Term Morphology of Functional Blebs Following Implantation of Preserflo MicroShunt Using AS-OCT.Translational vision science & technology · 2023Article
- Reduction of experimental ocular axial elongation by neuregulin-1 antibody.Frontiers in medicine · 2023Article
- TGF-β2 levels in the aqueous humor are elevated in the second eye of high myopia within two weeks after sequential cataract surgery.Scientific reports · 2022Article
- TGF-β-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells.Investigative ophthalmology & visual science · 2022Article
- Scleral remodeling in myopia development.International journal of ophthalmology · 2022Review
- Intraocular epidermal growth factor concentration, axial length, and high axial myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Association between ocular axial length and anthropometrics of Asian adults.BMC research notes · 2021Article
- Association of Myopia and Genetic Variants ofFrontiers in cell and developmental biology · 2021Article
- Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients.International journal of medical sciences · 2021Observational
- The expression of cytokines in aqueous humor of high myopic patients with cataracts.Molecular vision · 2020Article
- A negative correlation of axial length with aqueous humor concentration of cytokines in patients with congenital cataracts.Molecular vision · 2020Article
- All-trans retinoic acid stimulates the secretion of TGF-β2 via the phospholipase C but not the adenylyl cyclase signaling pathway in retinal pigment epithelium cells.BMC ophthalmology · 2019Article
- Significant Association and Increased Risk of Primary Open Angle Glaucoma withReports of biochemistry & molecular biology · 2019Article
- Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases.Biomedical reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the relationship between transforming growth factor-beta 2 (TGF- β 2) levels in the anterior chamber aqueous humor and axial length of patients with myopia.
methodsTGF- β 2 was measured with the Luminex xMAP Technology by using commercially available Milliplex xMAP Kits. Sixty-five aqueous humor samples were collected during cataract or clear lens extraction surgery and TGF- β 2 levels in these specimens were analyzed. According to the axial length, the samples were divided into three groups: A (AL ≤ 24 mm), B (24 ~ 29 mm), and C (AL ≥ 29 mm).
resultsAqueous humor samples were analyzed from subjects with an average age of 67.0 ± 11.7 years. Mean TGF- β 2 concentration of all aqueous samples was 422.2 ± 258.8 pg/mL. TGF- β 2 concentration in group C (543 ± 317 pg/mL) was significantly greater than that in group A (390 ± 212 pg/mL) and group B (337 ± 217 pg/mL). The concentration of TGF- β 2 was positively correlated with axial length (r = 0.308, P = 0.013).
conclusionsTGF- β 2 is likely to be acting as a critical factor in axial elongation and development of myopia.
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