Evidence map›Paper›PMID 24967335›Full record

Trial reportBioMed research international2014

Multiple determinations of sperm DNA fragmentation show that varicocelectomy is not indicated for infertile patients with subclinical varicocele.

Agustín García-Peiró, Jordi Ribas-Maynou, María Oliver-Bonet, Joaquima Navarro, Miguel A Checa, Alexandros Nikolaou, María J Amengual, Carlos Abad, Jordi Benet

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Sperm chromatin structure assay (SCSABasic and clinical andrology · 2023
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020
    Review
  8. Article
  9. Effect of varicocele repair on sperm DNA fragmentation: a review.International urology and nephrology · 2018
    Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Agustín García-PeiróDepartament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain ; Càtedra de Recerca Eugin, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain ; Centro de Infertilidad Masculina y Análisis de Barcelona (CIMAB), Edifici Eureka, PBM5, Parc de Recerca de la UAB (PRUAB), 08193 Bellaterra, Spain.
Jordi Ribas-MaynouDepartament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
María Oliver-BonetDepartament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Joaquima NavarroDepartament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Miguel A ChecaDepartament de Obstetricia i Ginecologia, Parc de Salut Mar, Universitat Autònoma de Barcelona, 08003 Barcelona, Spain ; Laboratorio de Andrología, CIRH, Clínica Corachan, ANACER, 08017 Barcelona, Spain.
Alexandros NikolaouCentro de Infertilidad Masculina y Análisis de Barcelona (CIMAB), Edifici Eureka, PBM5, Parc de Recerca de la UAB (PRUAB), 08193 Bellaterra, Spain.
María J AmengualUDIAT, Centre Diagnòstic, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí, UAB, 08208 Sabadell, Spain.
Carlos AbadServei d'Urologia, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí, UAB, 08208 Sabadell, Spain.
Jordi BenetDepartament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Universitat Autònoma de Barcelona · ESCorporació Sanitària Parc Taulí · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele.

Indexed as

DNA FragmentationCohort StudiesHumansInfertility, MaleMaleSpermatozoaVaricocele

Identifiers

PMID24967335
PMCPMC4055098
OpenAlexW2137999686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.