ReviewFrontiers in chemistry2014
Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties.
Review in Frontiers in chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 127 citations in OpenAlex.
- Article
- Sequential soxhlet fractionation ofFrontiers in chemistry · 2026Article
- Evaluation of the phytochemical profile, biological activities, and acute toxicity ofFrontiers in chemistry · 2026Article
- Review
- Biology, Antioxidant Activity, and Therapeutic Potential ofInternational journal of molecular sciences · 2025Review
- De novo transcriptome assembly of the plant Helianthemum marifolium for the study of adaptive mechanisms.Scientific data · 2025Article
- Phytochemical Profile and In Vitro Cytotoxic, Genotoxic, and Antigenotoxic Evaluation ofInternational journal of molecular sciences · 2024Article
- Characterising the Metabolomic Diversity and Biological Potentials of Extracts from Different Parts of TwoPathogens (Basel, Switzerland) · 2024Article
- Variations of floral temperature in changing weather conditions.Ecology and evolution · 2024Article
- Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile ofAntioxidants (Basel, Switzerland) · 2024Article
- Chemical and transcriptomic analyses of leaf trichomes from Cistus creticus subsp. creticus reveal the biosynthetic pathways of certain labdane-type diterpenoids and their acetylated forms.Journal of experimental botany · 2024Article
- Labdanum Resin fromMolecules (Basel, Switzerland) · 2024Article
- Efficacy of Two MoroccanMolecules (Basel, Switzerland) · 2023Article
- Polyphenol Profile ofAntioxidants (Basel, Switzerland) · 2023Article
- Artificial Intelligence Applied to Improve Scientific Reviews: The Antibacterial Activity ofAntibiotics (Basel, Switzerland) · 2023Article
- Triterpenoid and Steroid Content of Lipophilic Extracts of Selected Medicinal Plants of the Mediterranean Region.Molecules (Basel, Switzerland) · 2023Article
- Phytochemistry and Antihyperglycemic Potential ofMolecules (Basel, Switzerland) · 2022Article
- Antifungal Potential of Canarian Plant Extracts against High-Risk Phytopathogens.Plants (Basel, Switzerland) · 2022Article
- Insight intoPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Antioxidant and Antiglycation Effects ofMolecules (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The family Cistaceae (Angiosperm, Malvales) consists of 8 genera and 180 species, with 5 genera native to the Mediterranean area (Cistus, Fumara, Halimium, Helianthemum, and Tuberaria). Traditionally, a number of Cistus species have been used in Mediterranean folk medicine as herbal tea infusions for healing digestive problems and colds, as extracts for the treatment of diseases, and as fragrances. The resin, ladano, secreted by the glandular trichomes of certain Cistus species contains a number of phytochemicals with antioxidant, antibacterial, antifungal, and anticancer properties. Furthermore, total leaf aqueous extracts possess anti-influenza virus activity. All these properties have been attributed to phytochemicals such as terpenoids, including diterpenes, labdane-type diterpenes and clerodanes, phenylpropanoids, including flavonoids and ellagitannins, several groups of alkaloids and other types of secondary metabolites. In the past 20 years, research on Cistus involved chemical, biological and phylogenetic analyses but recent investigations have involved genomic and molecular approaches. Our lab is exploring the biosynthetic machinery that generates terpenoids and phenylpropanoids, with a goal to harness their numerous properties that have applications in the pharmaceutical, chemical and aromatic industries. This review focuses on the systematics, botanical characteristics, geographic distribution, chemical analyses, biological function and biosynthesis of major compounds, as well as genomic analyses and biotechnological approaches of the main Cistus species found in the Mediterranean basin, namely C. albidus, C. creticus, C. crispus, C. parviflorus, C. monspeliensis, C. populifolius, C. salviifolius, C. ladanifer, C. laurifolius, and C. clusii.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.