Evidence map›Paper›PMID 24967217›Full record

ArticleGerms2014

Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis in children below five years of age in Romania.

Ioana Alina Anca, Florentina Ligia Furtunescu, Doina Pleşca, Adrian Streinu-Cercel, Sorin Rugină, Katsiaryna Holl

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Germs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01253967 (Hospital-based Surveillance to Estimate the Disease Burden of Rotavirus Gastroenteritis in Children < 5 Years of Age in Romania), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01253967 completednot on this map

Hospital-based Surveillance to Estimate the Disease Burden of Rotavirus Gastroenteritis in Children < 5 Years of Age in Romania

TypeobservationalSponsorGlaxoSmithKlineRan2008 to 2010Enrolled1,234ConditionsInfections, RotavirusArmsCollection of stool samples, Health economics questionnaire
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioana Alina AncaMD, PhD, Carol Davila University of Medicine and Pharmacy; Institute For Mother and Child Care, Bucharest 020395, Romania.
Florentina Ligia FurtunescuMD, PhD, Department of Complementary Sciences, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050463, Romania.
Doina PleşcaMD, PhD, Carol Davila University of Medicine and Pharmacy; Children's Clinical Hospital "Dr. Victor Gomoiu", Bucharest 022102, Romania.
Adrian Streinu-CercelMD, PhD, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; National Institute for Infectious Diseases "Prof. Dr. Matei Balş", Bucharest 021105, Romania.
Sorin RuginăMD, PhD, Ovidius University, Faculty of Medicine, Infectious Diseases Clinic, Constanţa 900709, Romania.
Katsiaryna HollMSc, PhD, GlaxoSmithKline Vaccines, Wavre 1300, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRotavirus (RV) is a leading cause of acute gastroenteritis (AGE), affecting 95% of children below five years of age.

methodsIn this prospective, multi-center study, children below five years of age who were hospitalized or those who visited the emergency room (ER) due to AGE or who developed AGE at least 48 hours after hospitalization (nosocomial infection) and had a RV-positive stool sample were included (n=1,222). RV-positive samples were genotyped by reverse-transcriptase polymerase chain reaction.

resultsRV test results were available for 1,212 children (hospitalizations [n=677], ER visits [n=398] and nosocomial AGE cases [n=137]). Proportions of rotavirus gastroenteritis (RVGE) hospitalizations and ER visits were 51.70% (350/677; 95%CI: 47.86-55.52) and 36.18% (144/398; 95%CI: 31.45-41.12), respectively. Overall, 45.95% (494/1075) of all community-acquired AGE cases were due to RV. High numbers of RVGE cases were recorded between January and March. Most common genotypes were G9P[8] (34.27%) followed by G4P[8] (25.83%) and G1P[8] (23.02%). Of all community-acquired RVGE cases, the highest number of cases was observed in children aged 12-23 months. Median duration of hospitalization among RV-positive subjects was six days (range: 2-31 days). Incidence of nosocomial RVGE was 0.52 (95%CI: 0.45-0.60) cases per 1,000 child-days hospitalization. Median duration for additional hospitalization due to nosocomial RVGE was five days (range: 1-10). The highest burden of nosocomial RVGE was observed in children aged 12-23 months (42.34%, 58/137). Our findings confirm a high burden of acute RVGE disease in Romania and provide useful data to support the implementation of RV vaccination in Romania.

trial registrationNCT01253967.

Indexed as

acute gastroenteritisepidemiologyincidencenosocomialRomaniaRotavirus

Identifiers

PMID24967217
PMCPMC4067607

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Registered trials

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