ReviewInternational journal of ophthalmology2014
The role of heredity in pterygium development.
Review in International journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Fibrin glue versus sutures for conjunctival autografting in primary pterygium surgery.The Cochrane database of systematic reviews · 2016Pooled it
- Extensive recurrent pterygium following photorefractive keratectomy: a case report.BMC ophthalmology · 2026Article
- Histone H3 lysine 9 tri-methylation is associated with pterygium.BMC ophthalmology · 2025Article
- Assessing genetic and environmental components for pterygium: a nationwide study in Taiwan.Scientific reports · 2024Article
- Expression Analysis of the Small GTP-Binding Protein Rac in PterygiumTurkish journal of ophthalmology · 2023Article
- Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment.Biomedicines · 2023Review
- The effect of limbal autograft location at primary pterygium excision on anterior and posterior corneal astigmatism: a comparative prospective study.International ophthalmology · 2022Observational
- Article
- Is Pterygium Morphology Related to Loss of Corneal Endothelial Cells? A Cross-Sectional Study.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Metabolomics analysis in pterygium tissue.International ophthalmology · 2019Article
- Expression of Inflammatory-Related NFκB Genes in Iranian Patients with Pterygium: A Case-Control Study.International journal of molecular and cellular medicine · 2018Article
- How to minimize pterygium recurrence rates: clinical perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2018Review
- Surgical outcome of conjunctival rotational autograft-mitomycin C (MMC) versus free conjunctival autograft-MMC for pterygium removal: A randomized clinical trial.Electronic physician · 2017Article
- Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium.International journal of immunopathology and pharmacology · 2017Article
- Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts.International journal of molecular medicine · 2017Article
- Pterygium: an update on pathophysiology, clinical features, and management.Therapeutic advances in ophthalmologyReview
- Contribution of Matrix Metalloproteinase-2 Genotypes to Taiwan Pterygium Risk.In vivo (Athens, Greece)Article
- Expression of Vitamin D Receptor and Vitamin D Receptor Gene Polymorphisms (BsmI, FokI, and TaqI) in Patients with Pterygium.Arquivos brasileiros de oftalmologiaArticle
- Carnitine analysis in pterygium.Arquivos brasileiros de oftalmologiaArticle
- Risk Factors for Pterygium in Ilam Province, Iran.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several risk factors, which include heredity, ultra-violet (UV) light and chronic inflammation, contribute to pterygium development. However, there is no report integrating these factors in the pathogenesis of pterygium. The aim of this review is to describe the connection between heredity, UV, and inflammation in pterygium development. Existing reports indicate that sunlight exposure is the main factor in pterygium occurrence by inducing growth factor production or chronic inflammation or DNA damage. Heredity may be a factor. Our studies on factors in pterygium occurrence and recurrence identify that heredity is crucial for pterygium to develop, and that sunlight is only a trigger, and that chronic inflammation promotes pterygium enlargement. We propose that genetic factors may interfere with the control of fibrovascular proliferation while UV light or (sunlight) most likely only triggers pterygium development by inducing growth factors which promote vibrant fibrovascular proliferation in predisposed individuals. It also just triggers inflammation and collagenolysis, which may be promoters of the enlargement of the fibrovascular mass. Pterygium probably occurs in the presence of exuberant collagen production and profuse neovascularisation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.