ArticleInternational journal of ophthalmology2014
Toxoplasma gondii infection can induce retinal DNA damage: an experimental study.
Article in International journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Pancreatic Pathological Changes in Murine Toxoplasmosis and Possible Association with Diabetes Mellitus.Biomedicines · 2022Article
- Ginger Is a Potential Therapeutic for Chronic Toxoplasmosis.Pathogens (Basel, Switzerland) · 2022Article
- Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- DNA double-strand breaks in the Toxoplasma gondii-infected cells by the action of reactive oxygen species.Parasites & vectors · 2020Article
- Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- In vivo effect of anti-TNF agent (etanercept) in reactivation of latent toxoplasmosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Characterization of the parasite-induced lesions in the posterior segment of the eye.Indian journal of ophthalmology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo detect whether Toxoplasma gondii (T. gondii) infection of mice can induce retinal DNA damage.
methodsA total of 20 laboratory-bred male Swiss albino mice were used and divided into four groups: control group (non-infected animals); T. gondii infected group; immunosuppressed infected group; and infected group treated with sulfadiazine and pyrimethamine. Mice eyes were collected 6wk post infection and retinas were obtained. Each retina was immediately processed for comet assay and the frequency of tailed nuclei (DNA damage) was calculated. In addition, retinal DNA damage was revealed by various comet assay parameters that were provided by the image analysis software including tail length, percentage of DNA in the tail, percentage of tailed cells and tail moment.
resultsThe obtained results showed that T. gondii infection induced a statistically significant increase in the frequency of tailed nuclei, tail length, percentage of DNA in the tail, and tail moment in mice retinal cells compared to the control group (which showed some degree of DNA damage). In immunosuppressed infected group, retinal DNA damage was severing and there was significant increase in various comet assay parameters compared to both control and infected groups. After treatment with sulfadiazine and pyrimethamine, retinal DNA damage decreased and all comet assay parameters showed a statistical significant decrease compared to infected groups.
conclusionT. gondii infection can induce DNA damage in mice retinal cells.
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