ArticleIranian journal of basic medical sciences2014
Mutations in pre-core and basal-core promoter regions of hepatitis B virus in chronic HBV patients from Golestan, Iran.
Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Molecular analysis of HBV pre-core gene mutations in patients co-infected with HIV at a tertiary care hospital in North India.Access microbiology · 2025Article
- The clinical value of serum hepatic parenchyma cell volume-normalized hepatitis B surface antigen levels in hepatitis B e antigen -positive and -negative chronic hepatitis B patients.Annals of translational medicine · 2021Article
- Hepatitis B virus reverse transcriptase polymorphisms between treated and treatment-naïve chronically infected patients.Virusdisease · 2019Article
- Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.Mediterranean journal of hematology and infectious diseases · 2019Article
- Mutations in Hepatitis-B X-Gene Region: Chronic Hepatitis-B versus Cirrhosis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Current progress in the development of therapeutic vaccines for chronic hepatitis B virus infection.Iranian journal of basic medical sciences · 2016Review
- Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients.World journal of gastroenterology · 2016Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIt has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC). In this study the PC and BCP mutations were investigated in chronic HBV patients. MATERIALS AND
methodsIn this study, 120 chronic HBV patients from Golestan, Northeast of Iran who were not vaccinated against HBV, were recruited from the year 2008 to 2012. HBV-DNA extraction from plasma and PCR were performed and positive PCR products were subjected to automated sequencing.
resultsOne hundred out of 120 (83.3%) patients were HBeAg negative. Comparison of our nucleotide sequences with reference sequence showed high rate mutation in BCP and PC region (96.66%). Frame shift mutation was found in 78 (65%) of patients in BCP region, among them 8 (6.6%) patients showed mutation in PC region.
conclusionOur results demonstrated high rate of mutations in BCP and PC regions among HBV chronic patients in Northeast of Iran.
Indexed as
Identifiers
24967066PMC4069846W1595176004What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.