Evidence map›Paper›PMID 24966952›Full record

ReviewInternational journal of clinical and experimental pathology2014

Clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma.

Rong Ge, Chuangfeng Liu, Xiangang Yin, Jinping Chen, Xincheng Zhou, Chunxin Huang, Wenying Yu, Xiaohan Shen

Abstract readCase ReportsReview
PubMed Full text at PMC
In one paragraph

Review in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Epstein-Barr virusOncology letters · 2026
    Article
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  5. Article
  6. Review
  7. Article
  8. Article
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  16. Review
  17. Laryngeal EBV-positive Inflammatory Follicular Dendritic cell/fibroblastic Reticular cell Tumour.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rong GeDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Chuangfeng LiuDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Xiangang YinDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Jinping ChenDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Xincheng ZhouDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Chunxin HuangDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Wenying YuDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.
Xiaohan ShenDepartment of Diagnosis, Ningbo Diagnostic Pathology Center Ningbo 315021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) sarcoma is a recently described rare tumor and considered a unique entity, with different histologic appearances and behavior from those of the classical FDC sarcoma. This study analyzed the clinical and pathological findings of two such cases that the authors encountered and 36 previously reported cases identified in the literature. Assessment of all 38 cases showed a slight female predominance (2.2:1) with a median age of 56.5 years. Seventeen patients complained of abdominal discomfort or pain, while fifteen patients had no clinical symptom. Almost all cases occurred in liver (n=20) or spleen (n=17). Except in one case, all patients underwent surgical resection of the tumor alone. Histologic features showed a mixture of chronic inflammatory cells and variable amounts of spindle cells with vesicular nuclei and distinct nucleoli. The tumor cells expressed conventional FDC markers such as CD21 (75%), CD35 (92%), CD23 (62%), clusterin (75%), and CNA.42 (100%). EBV was detected in thirty-five cases (92.1%) by Epstein-Barr virus (EBV)-encoded RNA in situ hybridization, and EBV-latent membrane protein-1 was expressed in 90% of the cases. With a median follow-up of 21 months, 29 patients (85.3%) were alive and well, 4 (11.8%) were alive with disease, one patient (2.9%) died of disease. Only four patients with hepatic tumors underwent recurrence or metastasis after initial treatment. Epstein-Barr virus is thought to play a role in the development of the tumor; however, the pathogenesis of the disease and the origin of tumor cells remain unclear.

Indexed as

Abdominal PainAgedBiomarkers, TumorBiopsyDendritic Cell Sarcoma, FollicularDendritic Cells, FollicularDNA, ViralFemaleGranuloma, Plasma CellHepatectomyHerpesvirus 4, HumanHumansImmunohistochemistryIn Situ HybridizationLiver NeoplasmsMaleBiomarkers, TumorDNA, ViralEpstein-Barr virusFollicular dendritic cell sarcomainflammatory pseudotumorliverspleen

Identifiers

PMID24966952
PMCPMC4069939

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.