Evidence map›Paper›PMID 24966951›Full record

ReviewInternational journal of clinical and experimental pathology2014

Primary atypical teratoid/rhabdoid tumor of central nervous system in children: a clinicopathological analysis and review of literature in China.

Min Yang, Xi Chen, Ning Wang, Kun Zhu, Ying-Zi Hu, Yun Zhao, Yan Shu, Man-Li Zhao, Wei-Zhong Gu, Hong-Feng Tang

Open access · greenAbstract readReview
In one paragraph

Review in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Prognostic factors of pediatric pineal region tumors at a single institution.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  4. Atypical teratoid rhabdoid tumours (ATRTs)-a 21-year institutional experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Min YangDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Xi ChenDepartment of Experimental Testing, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Ning WangDepartment of Neurosurgery, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Kun ZhuDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Ying-Zi HuDepartment of Radiology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Yun ZhaoDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Yan ShuDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Man-Li ZhaoDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Wei-Zhong GuDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Hong-Feng TangDepartment of Pathology, Children's Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.
Children's Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical teratoid/rhabdoid tumor (AT/RT) is a very rare and highly malignant embryonal tumor in the central nervous system (CNS). Five patients (4 girls and 1 boy) with AT/RT were treated in our hospital. The clinical histories, symptoms, neuroimaging aspects, therapies, histological and immunohistochemical findings and follow-up information were reviewed. The patients ranged from 8 to 40 months with a mean age of 20.6 months. One tumor was located in the spinal cord, two in cerebellum and two in the pineal region. The imagings of the tumors resemble medulloblastomas. Pathological examinations showed that one patient had medulloblastoma differentiation, one had choroid plexus carcinoma differentiation, and one had mesenchymal components. Immunohistochemical staining showed that all of the tumors lost the nuclear expression of integrase interactor 1 (INI1), and were positive for Vimentin, S-100 protein and epithelial membrane antigen. One case with no recurrence after 24 months may have benefited from radical excision and postoperative radiotherapy. The other 4 patients died 8, 4, 1 and 1-month respectively after operation without radiotherapy. The diagnosis of AT/RT depends on full sampling, careful observation the morphological characteristics and INI1 examination, even when the tumor are presented in uncommon sites, such as the spinal cord and the pineal region.

Indexed as

Age FactorsBiomarkers, TumorBiopsyCell DifferentiationCentral Nervous System NeoplasmsChild, PreschoolChinaFemaleHumansImmunohistochemistryInfantMagnetic Resonance ImagingMalePredictive Value of TestsRhabdoid TumorTeratomaBiomarkers, TumorAtypical teratoid/rhabdoid tumorcerebellumintegrase interactor 1pineal glandspinal cord

Identifiers

PMID24966951
PMCPMC4069879
OpenAlexW57367861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.