ArticleFrontiers in behavioral neuroscience2014
A new approach to assess gambling-like behavior in laboratory rats: using intracranial self-stimulation as a positive reinforcer.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Sexual Differences in Internet Gaming Disorder (IGD): From Psychological Features to Neuroanatomical Networks.Journal of clinical medicine · 2022Review
- Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017Review
- Pharmacologically distinct pramipexole-mediated akinesia vs. risk-taking in a rat model of Parkinson's disease.Progress in neuro-psychopharmacology & biological psychiatry · 2016Article
- Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task.PloS one · 2015Article
- Neuronal and psychological underpinnings of pathological gambling.Frontiers in behavioral neuroscience · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Pathological gambling is one manifestation of impulse control disorders. The biological underpinnings of these disorders remain elusive and treatment is far from ideal. Animal models of impulse control disorders are a critical research tool for understanding this condition and for medication development. Modeling such complex behaviors is daunting, but by its deconstruction, scientists have recapitulated in animals critical aspects of gambling. One aspect of gambling is cost/benefit decision-making wherein one weighs the anticipated costs and expected benefits of a course of action. Risk/reward, delay-based and effort-based decision-making all represent cost/benefit choices. These features are studied in humans and have been translated to animal protocols to measure decision-making processes. Traditionally, the positive reinforcer used in animal studies is food. Here, we describe how intracranial self-stimulation can be used for cost/benefit decision-making tasks and overview our recent studies showing how pharmacological therapies alter these behaviors in laboratory rats. We propose that these models may have value in screening new compounds for the ability to promote and prevent aspects of gambling behavior.
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Registered trials
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