SynthesisWorld journal of gastroenterology2014
Association between orofacial granulomatosis and Crohn's disease in children: systematic review.
Synthesis in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Orofacial granulomatosis associated with Crohn's disease: clinical phenotype and response to biologics and Janus kinase inhibitor therapy in a large multi-center cohort.Journal of Crohn's & colitis · 2026Article
- Article
- Fecal microbiota and genetics in pediatric-onset orofacial granulomatosis and Crohn´s disease.Scientific reports · 2025Article
- Orofacial Granulomatosis and Crohn's Disease: A Case Series.ACG case reports journal · 2024Article
- Managing Crohn's Disease Postoperative Recurrence Beyond Prophylaxis: A Comprehensive Review with Meta-Analysis.Biomedicines · 2024Review
- Combined wedge resection for lower lip debulking in Melkersson-Rosenthal syndrome.Pediatric discovery · 2024Article
- Melkersson-Rosenthal syndrome: A case report.Clinical case reports · 2024Article
- Frequent Occurrence of Perianal Disease and Granuloma Formation in Patients with Crohn's Disease and Coexistent Orofacial Granulomatosis.Digestive diseases and sciences · 2023Article
- Identification of Putative Bacterial Pathogens for Orofacial Granulomatosis Based on 16S rRNA Metagenomic Analysis.Microbiology spectrum · 2023Article
- Cutaneous Manifestations of Inflammatory Bowel Disease: A Basic Overview.American journal of clinical dermatology · 2022Review
- Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.Gastroenterology · 2021Review
- Lip swelling with lymphangiectasia.JAAD case reports · 2021Article
- Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in China.JAAD international · 2020Article
- Orofacial granulomatosis: a questionnaire study among Norwegian dental clinicians.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020Article
- A Case of Cheilitis Granulomatosa/Orofacial Granulomatosis.Clinical, cosmetic and investigational dentistry · 2020Article
- Non-infectious Granulomatous Lesions of the Orofacial Region.Head and neck pathology · 2019Review
- The difference in extraintestinal manifestations of inflammatory bowel disease for children and adults.Translational pediatrics · 2019Review
- Gastrointestinal diseases and their oro-dental manifestations: Part 1: Crohn's disease.British dental journal · 2016Review
- The role of exclusive enteral nutrition in the management of orofacial granulomatosis in children.World journal of pediatrics : WJP · 2016Article
- Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease.Clinical journal of gastroenterology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo review pediatric cases of orofacial granulomatosis (OFG), report disease characteristics, and explore the association between OFG and Crohn's disease.
methodsWe conducted a systematic review according to the PRISMA guidelines. We searched Medline, LILACS, Virtual Health Library, and Web of Knowledge in September 2013 for cases of OFG in the pediatric age range (< 18 years), with no language limitations. All relevant articles were accessed in full text. The manual search included references of retrieved articles. We extracted data on patients' characteristics, disease characteristics, association with other diseases, and treatment. We analyzed the data and reported the results in tables and text.
resultsWe retrieved 173 reports of OFG in children. Mean age at onset was 11.1 ± 3.8 years (range: 2.0-18 years). Prevalence in males was significant higher than in females (P < 0.001), with a male:female ratio of 2:1. Gastrointestinal signs or symptoms were present in 26.0% of children at the time of OFG diagnosis. Overall, 70/173 (40.4%) children received a concomitant diagnosis of Crohn's disease. In about half (51.4%) of the cases the onset of OFG anticipated the diagnosis of Crohn's disease, with a mean time between the two diagnoses of 13.1 ± 11.6 mo (range: 3-36 mo). Overall, 21/173 (12.1%) of the children with OFG had perianal disease, while 11/173 (6.4%) had a family history of Crohn's disease. Both perianal disease and a family history of Crohn's disease were significantly associated with a higher risk of Crohn's disease diagnosis in children with OFG [relative risk (RR) = 3.10, 95% confidence interval (CI): 2.46-3.90; RR = 2.74, 95%CI: 2.24-3.36, P < 0.0001 for both). Treatment of OFG included steroids (70.8% of children) and other immunosuppressive drugs (42.7%), such as azathioprine, thalidomide and infliximab.
conclusionHigh prevalence of Crohn's disease in children with OFG suggests that OFG may be a subtype of Crohn's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.