ReviewWorld journal of gastroenterology2014
Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Metabolic characteristics in hepatocellular carcinoma: amino acid metabolic reprogramming.Molecular cancer · 2026Review
- Research advances in branched-chain amino acid metabolism in tumors.Molecular and cellular biochemistry · 2025Review
- Multi-omics analysis identifies BCAT2 as a potential pan-cancer biomarker for tumor progression and immune microenvironment modulation.Scientific reports · 2024Article
- The efficacy of branched-chain amino acid granules to restore phagocytic activity in cirrhosis patients, a randomized controlled trial.Frontiers in nutrition · 2023Article
- Metabolomics profile in acute respiratory distress syndrome by nuclear magnetic resonance spectroscopy in patients with community-acquired pneumonia.Respiratory research · 2022Article
- The Gut Microbiota: A Novel Player in Autoimmune Hepatitis.Frontiers in cellular and infection microbiology · 2022Review
- Effects of Inclusion ofAnimals : an open access journal from MDPI · 2021Article
- Amino acids and the regulation of oxidative stress and immune function in dairy cattle.Journal of animal science · 2020Article
- Mechanisms of Resistance toFrontiers in microbiology · 2020Review
- The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids.Frontiers in endocrinology · 2019Review
- The Value of the C-Reactive Protein-to-Albumin Ratio is Useful for Predicting Survival of Patients with Child-Pugh Class A Undergoing Liver Resection for Hepatocellular Carcinoma.World journal of surgery · 2018Article
- Branched Chain Amino Acids: Beyond Nutrition Metabolism.International journal of molecular sciences · 2018Review
- Dietary and metabolic modulators of hepatic immunity.Seminars in immunopathology · 2018Review
- Branched-chain amino acids in liver diseases.Translational gastroenterology and hepatology · 2018Review
- High throughput data analyses of the immune characteristics of Microtus fortis infected with Schistosoma japonicum.Scientific reports · 2017Article
- Novel metabolic and physiological functions of branched chain amino acids: a review.Journal of animal science and biotechnology · 2017Review
- Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver function.World journal of gastroenterology · 2016Review
- Essential amino acid supplementation is associated with reduced serum C-reactive protein levels and improved circulating lymphocytes in post-acute inflamed elderly patients.International journal of immunopathology and pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that host defense responses, such as phagocytic function of neutrophils and natural killer (NK) cell activity of lymphocytes, are impaired in cirrhotic patients. This review will concentrate on the impairment of innate immune responses in decompensated cirrhotic patients and the effect of the treatment by branched-chain amino acids (BCAA) on innate immune responses. We already reported that phagocytic function of neutrophils was significantly improved by 3-mo BCAA supplementation. In addition, the changes of NK activity were also significant at 3 mo of supplementation compared with before supplementation. Also, Fisher's ratios were reported to be significantly increased at 3 mo of BCAA supplementation compared with those before oral supplementation. Therefore, administration of BCAA could reduce the risk of bacterial and viral infection in patients with decompensated cirrhosis by restoring impaired innate immune responses of the host. In addition, it was also revealed that BCAA oral supplementation could reduce the risk of development of hepatocellular carcinoma in cirrhotic patients. The mechanisms of the effects will also be discussed in this review article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.