ReviewWorld journal of gastroenterology2014
Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Pooled it
- Observational
- Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact.World journal of clinical cases · 2026Article
- Polysplenia syndrome complicated by multiple intrahepatic bile duct stones in an adult: a case report.Frontiers in medicine · 2026Article
- Opposition Research: Endoscopic Management of Acute Cholecystitis in Patients with Decompensated Cirrhosis.Digestive diseases and sciences · 2025Article
- Cystic Duct Stenting Versus Other Treatment Modalities for the Management of Acute Cholecystitis in Patients with Decompensated Cirrhosis.Digestive diseases and sciences · 2025Article
- Cholecystectomy in the Context of Cirrhosis, Sclero-Atrophic Cholecystitis, and Gangrenous Cholecystitis: A Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Association between C-reactive protein to lymphocyte ratio and gallstones: a cross-sectional study.BMC gastroenterology · 2025Article
- Association of cardiometabolic index with gallstone disease and insulin resistance based on NHANES data.BMC gastroenterology · 2025Article
- Contracted or Vanishing Gallbladder: A Case Report.Cureus · 2025Article
- Association between visceral lipid accumulation indicators and gallstones: a cross-sectional study based on NHANES 2017-2020.Lipids in health and disease · 2024Article
- A Case of Robotic Cholecystectomy in a Patient With Decompensated Cirrhosis and Portal Hypertension.Cureus · 2024Article
- Associations of gallbladder and gallstone parameters with clinical outcomes in patients with cirrhosis.Journal of translational internal medicine · 2024Article
- Role of the circular RNA regulatory network in the pathogenesis of biliary atresia.Experimental and therapeutic medicine · 2024Article
- Review
- Dietary fatty acids and gallstone risk: insights from NHANES and Mendelian randomization analysis.Frontiers in nutrition · 2024Article
- Beneficial Alterations of Intestinal Microbiota in Chronic Cholecystitis Patients Treated With NOTES Gallbladder-Preserving Surgery.Gastroenterology research and practice · 2024Article
- Preoperative risk evaluation and optimization for patients with liver disease.Gastroenterology report · 2024Review
- Analysis of risk factors for the increased incidence of gallstone caused by hepatectomy: A retrospective case-control study.Frontiers in surgery · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallstones occur in about one third of the patients having liver cirrhosis. Pigment gallstones are the most frequent type, while cholesterol stones represent about 15% of all stones in cirrhotics. Increased secretion of unconjugated bilirubin, increased hydrolysis of conjugated bilirubin in the bile, reduced secretion of bile acids and phospholipds in bile favor pigment lithogenesis in cirrhotics. Gallbladder hypomotility also contributes to lithogenesis. The most recent data regarding risk factors for gallstones are presented. Gallstone prevalence increases with age, with a ratio male/female higher than in the general population. Chronic alcoholism, viral C cirrhosis, and non-alcoholic fatty liver disease are the underlying liver diseases most often associated with gallstones. Gallstones are often asymptomatic, and discovered incidentally. If asymptomatic, expectant management is recommended, as for asymptomatic gallstones in the general population. However, a closer follow-up of these patients is necessary in order to earlier treat symptoms or complications. For symptomatic stones, laparoscopic cholecystectomy has become the therapy of choice. Child-Pugh class and MELD score are the best predictors of outcome after cholecystectomy. Patients with severe liver disease are at highest surgical risk, therefore gallstone complications should be treated using noninvasive or minimally invasive procedures, until stabilization of the patient condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.