ReviewWorld journal of gastroenterology2014
New determinants of prognosis in bacterial infections in cirrhosis.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- ATTIRE: Albumin To prevenT Infection in chronic liveR failurE: study protocol for a single-arm feasibility trial.BMJ open · 2016Trial
- Impact of cirrhosis on patients admitted with an exacerbation of acute chronic obstructive pulmonary disease: a nationwide analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- PREVALENCE AND FACTORS ASSOCIATED WITH BACTERIAL INFECTION IN CIRRHOTIC PATIENTS IN TOGO.Arquivos de gastroenterologia · 2025Article
- Impact of pre-transplant infection management on the outcome of living-donor liver transplantation in Egypt.Infection and drug resistance · 2019Article
- ATTIRE: Albumin To prevenT Infection in chronic liveR failurE: study protocol for an interventional randomised controlled trial.BMJ open · 2018Article
- Intensive Care Therapy for Patients with Advanced Liver Diseases.Visceral medicine · 2018Review
- An Insight into Antibiotic Resistance to Bacterial Infection in Chronic Liver Disease.Journal of clinical and experimental hepatology · 2017Article
- Endothelial Cell Response to Fusobacterium nucleatum.Infection and immunity · 2016Article
- Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences.Liver international : official journal of the International Association for the Study of the Liver · 2016Article
- von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis.World journal of gastroenterology · 2016Article
- Endoscopic submucosal dissection in early gastric cancer in elderly patients and comorbid conditions.World journal of gastrointestinal endoscopy · 2015Review
- Multiresistant bacterial infections in liver cirrhosis: Clinical impact and new empirical antibiotic treatment policies.World journal of hepatology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite major advances in the knowledge and management of liver diseases achieved in recent decades, decompensation of cirrhosis still carries a high burden of morbidity and mortality. Bacterial infections are one of the main causes of decompensation. It is very important for clinical management to be aware of the population with the highest risk of poor outcome. This review deals with the new determinants of prognosis in patients with cirrhosis and bacterial infections reported recently. Emergence of multiresistant bacteria has led to an increasing failure rate of the standard empirical antibiotic therapy recommended by international guidelines. Moreover, it has been recently reported that endothelial dysfunction is associated with the degree of liver dysfunction and, in infected patients, with the degree of sepsis. It has also been reported that relative adrenal insufficiency is frequent in the non-critically ill cirrhotic population and it is associated with a higher risk of developing infection, severe sepsis, hepatorenal syndrome and death. We advise a change in the standard empirical antibiotic therapy in patients with high risk for multiresistant infections and also to take into account endothelial and adrenal dysfunction in prognostic models in hospitalized patients with decompensated cirrhosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.