ReviewWorld journal of gastroenterology2014
Influence of unrecorded alcohol consumption on liver cirrhosis mortality.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How does alcohol use impact morbidity and mortality of liver cirrhosis? A systematic review and dose-response meta-analysis.Hepatology international · 2024Pooled it
- The relationship between different dimensions of alcohol use and the burden of disease-an update.Addiction (Abingdon, England) · 2017Pooled it
- Berberine alleviates alcoholic liver diseaseactivating intestinal nuclear receptor subfamily 1 group D member 1.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Socio-economic factors associated with alcohol and cannabis use across waves of the COVID-19 pandemic: an intersectional analysis of a repeated cross-sectional survey.BMC public health · 2025Article
- Heavy metals in unrecorded Albanian rakia: A pilot study on a potential public health risk.Heliyon · 2023Article
- Burden of diseases and injuries attributable to alcohol consumption in the Middle East and North Africa region, 1990-2019.Scientific reports · 2022Article
- Self-reported mental health during the COVID-19 pandemic and its association with alcohol and cannabis use: a latent class analysis.BMC psychiatry · 2022Article
- Alcohol and cannabis use during the COVID-19 pandemic among transgender, gender-diverse, and cisgender adults in Canada.BMC public health · 2022Article
- The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease.JCI insight · 2021Article
- Reaction of the Liver upon Long-Term Treatment of Fluoxetine and Atorvastatin Compared with Alcohol in a Mouse Model.Journal of toxicology · 2021Article
- Toxicity of humidifier disinfectant polyhexamethylene guanidine hydrochloride by two-week whole body-inhalation exposure in rats.Journal of toxicologic pathology · 2020Article
- Is There a Need for Alcohol Policy to Mitigate Metal Contamination in Unrecorded Fruit Spirits?International journal of environmental research and public health · 2020Article
- Article
- Efficacy of furosemide for treatment of liver cirrhosis: A systematic review protocol of randomized controlled trial.Medicine · 2019Article
- Prevalence and determinants of heavy episodic drinking among adults in Kenya: analysis of the STEPwise survey, 2015.BMC public health · 2018Article
- Alcohol-Related Causes of Death and Drinking Patterns in Moldova as Compared to Russia and Ukraine.European journal of population = Revue europeenne de demographie · 2017Article
- High Ethanol Contents of Spirit Drinks in Kibera Slums, Kenya: Implications for Public Health.Foods (Basel, Switzerland) · 2017Article
- Alcoholic Liver Disease in Asia, Europe, and North America.Gastroenterology · 2016Article
- Traditional grain alcohol (bai jiu, [Symbol: see text]) production and use in rural central China: implications for public health.BMC public health · 2015Article
- Overview of Complications in Cirrhosis.Journal of clinical and experimental hepatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unrecorded alcohol includes illegally distributed alcohol as well as homemade or surrogate alcohol which is unintended for consumption by humans (e.g., cosmetics containing alcohol). The highest unrecorded alcohol consumption occurs in Eastern Europe and some of these countries have an over proportional liver cirrhosis mortality. Compounds besides ethanol have been hypothesized as being responsible for this observation. On the other hand, chemical investigations were unable to prove that unrecorded alcohol regularly contains contaminants above toxicological thresholds. However, illegally produced spirits regularly contain higher percentages of alcohol (above 45% by volume), but for considerably less costs compared with licit beverages, potentially causing more problematic patterns of drinking. In this review, it is investigated whether patterns of drinking rather than product composition can explain the liver cirrhosis mortality rates. Statistical examination of World Health Organization country data shows that the originally detected correlation of the percentage of unrecorded alcohol consumption and liver cirrhosis mortality rates disappears when the data is adjusted for the prevalence of heavy episodic drinking. It may be concluded that there is currently a lack of data to demonstrate causality between the composition of illicit spirits (e.g., higher levels of certain contaminants in home-produced products) and liver toxicity on a population scale. Exceptions may be cases of poisoning with antiseptic liquids containing compounds such as polyhexamethyleneguanidine, which were reported to be consumed as surrogate alcohol in Russia, leading to an outbreak of acute cholestatic liver injury, histologically different from conventional alcoholic liver disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.