ArticleAntimicrobial agents and chemotherapy1989
Inhibition of Pseudomonas aeruginosa exoenzyme expression by subinhibitory antibiotic concentrations.
Article in Antimicrobial agents and chemotherapy, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 97 citations in OpenAlex.
- Fluoroquinolones in the treatment of cystic fibrosis: a critical appraisal.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1991Trial
- Sub-Inhibitory Antibiotic Exposure and Virulence inAntibiotics (Basel, Switzerland) · 2021Review
- Bacterial Responses and Genome Instability Induced by Subinhibitory Concentrations of Antibiotics.Antibiotics (Basel, Switzerland) · 2013Review
- Potential virulence-associated properties of Plesiomonas shigelloides strains.Folia microbiologica · 2004Article
- Some properties of Plesiomonas shigelloides treated with aminoglycosides.Folia microbiologica · 2003Article
- Review
- Comparison of two culture methods for detection of tobramycin-resistant gram-negative organisms in the sputum of patients with cystic fibrosis.Journal of clinical microbiology · 2002Article
- Toxinogenicity and markers of pathogenicity of Pseudomonas aeruginosa strains isolated from patients with tumor diseases.Folia microbiologica · 2002Article
- Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis.Antimicrobial agents and chemotherapy · 2000Article
- The in vitro effect of imipenem and ofloxacin on enzymic activity of Klebsiella strains.Folia microbiologica · 2000Article
- Beneficial effect of adjunctive azithromycin in treatment of mucoid Pseudomonas aeruginosa pneumonia in the murine model.Antimicrobial agents and chemotherapy · 1999Article
- Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Alterations in surface hydrophobicity of Acinetobacter baumannii induced by meropenem.Folia microbiologica · 1999Article
- Effects of ginseng treatment on neutrophil chemiluminescence and immunoglobulin G subclasses in a rat model of chronic Pseudomonas aeruginosa pneumonia.Clinical and diagnostic laboratory immunology · 1998Article
- Pseudomonas aeruginosa exoenzyme S is a mitogen but not a superantigen for human T lymphocytes.Infection and immunity · 1998Article
- Review
- Pseudomonas aeruginosa and cystic fibrosis: Antibiotic therapy and the science behind the magic.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 1997Article
- Hydrophobicity and outer membrane proteins of Shigella dysenteriae type 1 after treatment with subinhibitory concentrations of aminoglycosides.Folia microbiologica · 1997Article
- Postantibiotic effects and postantibiotic sub-MIC effects of ciprofloxacin, pefloxacin and amikacin on the biological properties of Salmonella strains.Folia microbiologica · 1997Article
- Precipitating Pseudomonas aeruginosa antibodies and antimicrobial therapy in cystic fibrosis patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effects of subinhibitory concentrations of ciprofloxacin, tobramycin, and ceftazidime on Pseudomonas aeruginosa exoenzyme expression in vitro and in vivo. Exotoxin A, exoenzyme S, phospholipase C, elastase, and total protease activities were suppressed by antibiotics at concentrations as low as 1/20 of the MIC over a 24-h period in broth. Continuous 10-day exposure of P. aeruginosa DG1 broth cultures to antibiotic levels equal to 1/10 of the MIC reduced exoenzyme S activity in all treatment groups. Elastase activity was reduced only by ciprofloxacin and tobramycin treatment. This suppressive effect of the antibiotics persisted throughout the 10 days and was not influenced by the increase in MIC of ciprofloxacin detected during the course of the experiment. Rats chronically infected with P. aeruginosa were treated with subinhibitory doses of antibiotics and compared with untreated controls. Bacterial numbers in lung homogenates from each of the four study groups were identical. However, the lungs from antibiotic-treated rats had significantly less histological damage than those from control rats (P less than 0.001). The protective effect was greatest for ciprofloxacin and tobramycin. Further, P. aeruginosa isolates from ciprofloxacin- and tobramycin-treated rats demonstrated significantly less exoenzyme S and elastase activity than isolates from untreated rats (P less than 0.001). Isolates from ceftazidime-treated lungs expressed less exoenzyme S activity (P less than 0.001) but an equivalent amount of elastase activity as isolates from controls. The suppression of P. aeruginosa exoenzymes may arrest progressive lung injury during chronic P. aeruginosa lung infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.